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Safinamide inhibits in vivo glutamate release in a rat model of Parkinson's disease
Related publications (39)
Impact of Mitofusin 2 in the Nucleus Accumbens on motivated behavior and underlying neurobiological mechanisms
The nucleus accumbens (NAc) is part of the ventral striatum and plays a major role in motivation and goal-directed behaviour. Increasing evidence implicates impairments in accumbal function in anxiety and depression, two conditions that are commonly accomp ...
EPFL2024Striatal Dopamine Signals and Reward Learning
Carl Petersen, Sylvain Crochet, Yanqi Liu, Parviz Ghaderi, Mauro Pulin, Anthony Pierre Robert Renard, Christos Sourmpis, Pol Bech Vilaseca, Meriam Malekzadeh, Robin François Virginien Dard
We are constantly bombarded by sensory information and constantly making decisions on how to act. In order to optimally adapt behavior, we must judge which sequences of sensory inputs and actions lead to successful outcomes in specific circumstances. Neuro ...
Oxford2023A Multiscale, Systems-Level, Neuropharmacological Model of Cortico-Basal Ganglia System for Arm Reaching Under Normal, Parkinsonian, and Levodopa Medication Conditions
Vignayanandam Ravindernath Muddapu
In order to understand the link between substantia nigra pars compacta (SNc) cell loss and Parkinson's disease (PD) symptoms, we developed a multiscale computational model that can replicate the symptoms at the behavioural level by incorporating the key ce ...
FRONTIERS MEDIA SA2022Cell Type-Specific Membrane Potential Changes in Dorsolateral Striatum Accompanying Reward-Based Sensorimotor Learning
Carl Petersen, Sylvain Crochet, Tanya C Sippy
The striatum integrates sensorimotor and motivational signals, likely playing a key role in reward-based learning of goal-directed behavior. However, cell type-specific mechanisms underlying reinforcement learning remain to be precisely determined. Here, w ...
OXFORD UNIV PRESS2021Glutaredoxin 1 Downregulation in the Substantia Nigra Leads to Dopaminergic Degeneration in Mice
Background Parkinson's disease (PD) is characterized by a severe loss of the dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Perturbation of protein thiol redox homeostasis has been shown to play a role in the dysregulation of cell ...
2020MRI-based brain volumetry and retinal optical coherence tomography as the biomarkers of outcome in acute methanol poisoning
Tobias Kober, Bénédicte Marie Maréchal
Background: Basal ganglia lesions are typical findings on magnetic resonance imaging (MRI) of the brain in survivors of acute methanol poisoning. However, no data are available on the association between the magnitude of damaged brain regions, serum concen ...
ELSEVIER2020Pronounced α-synuclein pathology in a seeding-based mouse model is not sufficient to induce mitochondrial respiration deficits in the striatum and amygdala
Maria del Carmen Sandi Perez, Hilal Lashuel, Johannes Burtscher, Jean-Christophe Copin
Increasing evidence suggests that crosstalk between α-synuclein pathology formation and mitochondrial dysfunction plays a central role in the pathogenesis of Parkinson’s disease and related synucleinopathies. While mitochondrial dysfunction is a well-studi ...
2020A Computational Model of Loss of Dopaminergic Cells in Parkinson's Disease Due to Glutamate-Induced Excitotoxicity
Srikanth Ramaswamy, Vignayanandam Ravindernath Muddapu
Parkinson's disease (PD) is a neurodegenerative disease associated with progressive and inexorable loss of dopaminergic cells in Substantia Nigra pars compacta (SNc). Although many mechanisms have been suggested, a decisive root cause of this cell loss is ...
2019Classification of degenerative parkinsonism subtypes by support-vector-machine analysis and striatal I-123-FP-CIT indices
Dimitri Nestor Alice Van De Ville, Maria Giulia Preti
ObjectivesTo provide an automated classification method for degenerative parkinsonian syndromes (PS) based on semiquantitative I-123-FP-CIT SPECT striatal indices and support-vector-machine (SVM) analysis.Methods(123)I-FP-CIT SPECT was performed at a singl ...
Springer2019The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
Hilal Lashuel, Bruno Claude Daniel Fauvet, Magdalena Zweckstetter, Sebastian Kugler
Sirtuin genes have been associated with aging and are known to affect multiple cellular pathways. Sirtuin 2 was previously shown to modulate proteotoxicity associated with age-associated neurodegenerative disorders such as Alzheimer and Parkinson disease ( ...
2017