Protein primary structureProtein primary structure is the linear sequence of amino acids in a peptide or protein. By convention, the primary structure of a protein is reported starting from the amino-terminal (N) end to the carboxyl-terminal (C) end. Protein biosynthesis is most commonly performed by ribosomes in cells. Peptides can also be synthesized in the laboratory. Protein primary structures can be directly sequenced, or inferred from DNA sequencess.
ProteinopathyIn medicine, proteinopathy ([pref. protein]; -pathy [suff. disease]; proteinopathies pl.; proteinopathic adj), or proteopathy, protein conformational disorder, or protein misfolding disease, is a class of diseases in which certain proteins become structurally abnormal, and thereby disrupt the function of cells, tissues and organs of the body. Often the proteins fail to fold into their normal configuration; in this misfolded state, the proteins can become toxic in some way (a toxic gain-of-function) or they can lose their normal function.
DecorinDecorin is a protein that in humans is encoded by the DCN gene. Decorin is a proteoglycan that is on average 90 - 140 kilodaltons (kDa) in molecular weight. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a protein core containing leucine repeats with a glycosaminoglycan (GAG) chain consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS). Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein.
Truncated tetrahedronIn geometry, the truncated tetrahedron is an Archimedean solid. It has 4 regular hexagonal faces, 4 equilateral triangle faces, 12 vertices and 18 edges (of two types). It can be constructed by truncating all 4 vertices of a regular tetrahedron at one third of the original edge length. A deeper truncation, removing a tetrahedron of half the original edge length from each vertex, is called rectification. The rectification of a tetrahedron produces an octahedron.
Conway polyhedron notationIn geometry, Conway polyhedron notation, invented by John Horton Conway and promoted by George W. Hart, is used to describe polyhedra based on a seed polyhedron modified by various prefix operations. Conway and Hart extended the idea of using operators, like truncation as defined by Kepler, to build related polyhedra of the same symmetry. For example, tC represents a truncated cube, and taC, parsed as t(aC), is (topologically) a truncated cuboctahedron. The simplest operator dual swaps vertex and face elements; e.
Rectification (geometry)In Euclidean geometry, rectification, also known as critical truncation or complete-truncation, is the process of truncating a polytope by marking the midpoints of all its edges, and cutting off its vertices at those points. The resulting polytope will be bounded by vertex figure facets and the rectified facets of the original polytope. A rectification operator is sometimes denoted by the letter r with a Schläfli symbol. For example, r{4,3} is the rectified cube, also called a cuboctahedron, and also represented as .
