Publication
Immune serum-activated human macrophages coordinate with eosinophils to immobilize Ascaris suum larvae
Related publications (52)
A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy
Jacques Fellay, Flavia Aurelia Shoko Hodel
Infectious agents contribute significantly to the global burden of diseases through both acute infection and their chronic sequelae. We leveraged the UK Biobank to identify genetic loci that influence humoral immune response to multiple infections. From 45 ...
Cambridge2024Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework
Andrea Pfeifer, Florence Gauye, Tariq Afroz, Monisha Ratnam
Optimal pharmacokinetic (PK) properties of therapeutic monoclonal antibodies (mAbs) are essential to achieve the desired pharmacological benefits in patients. To accomplish this, we followed an approach comprising structure-based mAb charge engineering in ...
TAYLOR & FRANCIS INC2023Acetate, a metabolic product of Heligmosomoides polygyrus, facilitates intestinal epithelial barrier breakdown in a FFAR2-dependent manner
Nicola Harris, Mario Michael Zaiss, Julia Esser-von Bieren, Luc Xavier Marie Lebon
Approximately 2 billion people worldwide and a significant part of the domestic livestock are infected with soil-transmitted helminths, of which many establish chronic infections causing substantial eco-nomic and welfare burdens. Beside intensive research ...
2022The interplay between human genetic variation, chronic inflammation and persistent infection: relevance for cardiovascular morbidity
Contemporary genomic approaches allow us to seek answers to biological questions that were previously out of reach. Genome-wide association studies (GWAS) have identified numerous genetic polymorphisms associated with human diseases, providing new insight ...
EPFL2022SPICA: Swiss portal for immune cell analysis
Nicolas Jean Philippe Guex, Christian Iseli
Single-cell transcriptomics allows the study of immune cell heterogeneity at an unprecedented level of resolution. The Swiss portal for immune cell analysis (SPICA) is a web resource dedicated to the exploration and analysis of single-cell RNA-seq data of ...
OXFORD UNIV PRESS2022Invasive Streptococcal Infection Can Lead to the Generation of Cross-Strain Opsonic Antibodies
The bacterium Streptococcus pyogenes is a common cause of both mild and severe human diseases resulting in substantial morbidity and mortality each year. No vaccines are available, and our understanding of the antibody response to this human pathogen is st ...
AMER SOC MICROBIOLOGY2022The Transcription Factor Nfix Requires RhoA-ROCK1 Dependent Phagocytosis to Mediate Macrophage Skewing during Skeletal Muscle Regeneration
Macrophages (MPs) are immune cells which are crucial for tissue repair. In skeletal muscle regeneration, pro-inflammatory cells first infiltrate to promote myogenic cell proliferation, then they switch into an anti-inflammatory phenotype to sustain myogeni ...
2020House dust mite drives proinflammatory eicosanoid reprogramming and macrophage effector functions
Nicola Harris, Julia Esser-von Bieren, Tiffany Babette Angélique Bouchery
Background Eicosanoid lipid mediators play key roles in type 2 immune responses, for example in allergy and asthma. Macrophages represent major producers of eicosanoids and they are key effector cells of type 2 immunity. We aimed to comprehensively track e ...
WILEY2019Intestinal helminths modulate the gut microbiome
Intestinal parasitic worms (commonly named intestinal helminths) affect close to one quarter of the world population and cause major losses for the livestock industry. These parasites establish chronic infections by modulation the immunity of their host. T ...
EPFL2018Genetic determinants of healthy human immune variance: from humoral response to microbiome diversity
Identifying the drivers of the observed interindividual variability of the human immune system is crucial to our understanding of infectious and immune-mediated diseases. The contribution of genetic and non-genetic factors to immunological differences betw ...
EPFL2018