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Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1
Related publications (34)
Follicular regulatory helper T cells control the response of regulatory B cells to a high-cholesterol diet
Aims B cell functions in the process of atherogenesis have been investigated but several aspects remain to be clarified. Methods and results In this study, we show that follicular regulatory helper T cells (T-FR) control regulatory B cell (B-REG) populatio ...
OXFORD UNIV PRESS2021Quantitative approaches to unravel bone marrow adipocyte site-specificity and its implication in hematopoiesis
Josefine Catharina Pedersen Tratwal
Over the last decade, bone marrow (BM) adipose tissue (BMAT) has emerged as a distinct adipose depot with unique metabolic properties and effects both in homeostasis and in the progression of disease.
We provide a first comprehensive review of existing an ...
EPFL2020The Transcription Factor Nfix Requires RhoA-ROCK1 Dependent Phagocytosis to Mediate Macrophage Skewing during Skeletal Muscle Regeneration
Macrophages (MPs) are immune cells which are crucial for tissue repair. In skeletal muscle regeneration, pro-inflammatory cells first infiltrate to promote myogenic cell proliferation, then they switch into an anti-inflammatory phenotype to sustain myogeni ...
2020The nuclear receptor corepressor NCoR1 regulates hematopoiesis and leukemogenesis in vivo
Johan Auwerx, Lulu Liu, Wei Zhang, Yao Zhang, Na Zhang
Enhanced understanding of normal and malignant hematopoiesis pathways should facilitate the development of effective clinical treatment strategies for hematopoietic malignancies. Nuclear receptor corepressor 1 (NCoR1) has been implicated in transcriptional ...
AMER SOC HEMATOLOGY2019Metabolic and microenvironmental strategies to accelerate hematopoietic recovery post-aplasia
Vasco Ledebur de Antas de Campos
The procedure-associated mortality rate of bone marrow transplantations (BMT) remains close to 25%. The BMT is therefore only indicated for life-threatening diseases, with no replacement of this technology to be expected in the foreseeable future. Modest i ...
EPFL2019Role of myeloid cells in mediating protection against parasitic helminth larvae
Helminth infections affect around one fourth of the world population living in the poorest regions of our planet. Helminths mainly cause debilitating chronic effects on health, development and nutritional status of infected people. The development of a vac ...
EPFL2017Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in LdIr(-/-) Mice
Non-alcoholic steatohepatitis (NASH) is characterized by liver steatosis and inflammation. Currently, the underlying mechanisms leading to hepatic inflammation are not fully understood and consequently, therapeutic options are poor. Non-alcoholic steatohep ...
Public Library of Science2016Targeting macrophages sensitizes chronic lymphocytic leukemia to apoptosis and inhibits disease progression
The role of monocytes/macrophages in the development and progression of chronic lymphocytic leukemia (CLL) is poorly understood. Transcriptomic analyses show that monocytes/macrophages and leukemic cells cross talk during CLL progression. Macrophage deplet ...
Elsevier2016Increased Myeloid Cell Production and Lung Bacterial Clearance in Mice Exposed to Cigarette Smoke
Pneumonia is a leading cause of hospitalization in patients with chronic obstructive pulmonary disease (COPD). Although most patients with COPD are smokers, the effects of cigarette smoke exposure on clearance of lung bacterial pathogens and on immune and ...
Amer Thoracic Soc2016Histology Staining Protocol Adaptation and Blood Smear Analysis
Once a bone substitute, previously seeded with human bone progenitor cells, is implanted in a femoral condyle of a rat, it’s of importance to determine the intensity of a cell-triggered immune response of the host. Different techniques can be used, such as ...
2016