Publication
Mechano-modulatory synthetic niches for liver organoid derivation
Related publications (33)
Advanced technologies to control stem-cell based organogenesis
Organoids represent the first in vitro cell culture systems that closely resemble native tissues in terms of cellular composition, architecture and key aspects of physiology. Through the discovery of these cultures, researchers could demonstrate that stem ...
EPFL2017Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease
Johan Auwerx, Kristina Schoonjans, Alessia Perino, Vera Monica Lemos Da Silva, Jun Yong Kim, Dongryeol Ryu, Elena Katsyuba, Hongbo Zhang, Keir Joe Menzies, Matthias Alexander Sokrates Stein, Karim Laurent Gariani, Pooja Jha
Background & Aims: To date, no pharmacological therapy has been approved for non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to evaluate the therapeutic potential of poly ADP-ribose polymerase (PARP) inhibitors in mouse models o ...
Elsevier Science Bv2017Human Hepatocyte-Derived Induced Pluripotent Stem Cells: MYC Expression, Similarities to Human Germ Cell Tumors, and Safety Issues
Marc Samuel Friedli, Carmen Maria Unzu Ezquerro
Induced pluripotent stem cells (iPSC) are a most promising approach to the development of a hepatocyte transplantable mass sufficient to induce long-term correction of inherited liver metabolic diseases, thus avoiding liver transplantation. Their intrinsic ...
2016Bioengineering approaches to emulate the stem cell niche
Stem cell therapies hold tremendous potential for tissue and organ regeneration. Yet, there remains significant need for better ex vivo culture and manipulation methods. On the one hand, many tissue-specific stem cells cannot be propagated without causing ...
EPFL2015Bioengineering approaches to guide stem cell-based organogenesis
Matthias Lütolf, Adrian Ranga, Nikolche Gjorevski
During organogenesis, various molecular and physical signals are orchestrated in space and time to sculpt multiple cell types into functional tissues and organs. The complex and dynamic nature of the process has hindered studies aimed at delineating morpho ...
Company of Biologists2014In Vitro Pancreas Organogenesis from Dispersed Mouse Embryonic Progenitors
Filippo De Franceschi, Anne Grapin-Botton, Chiara Greggio
The pancreas is an essential organ that regulates glucose homeostasis and secretes digestive enzymes. Research on pancreas embryogenesis has led to the development of protocols to produce pancreatic cells from stem cells. The whole embryonic organ can be c ...
Journal Of Visualized Experiments2014Artificial three-dimensional niches deconstruct pancreas development in vitro
Matthias Lütolf, Filippo De Franceschi, Anne Grapin-Botton, Adrian Ranga, Samy Gobaa, Chiara Greggio
In the context of a cellular therapy for diabetes, methods for pancreatic progenitor expansion and subsequent differentiation into insulin-producing beta cells would be extremely valuable. Here we establish three-dimensional culture conditions in Matrigel ...
Company Of Biologists Ltd2013Differentiation of human embryonic stem cells to hepatocytes
Many liver diseases involve hepatocyte malfunction. In most cases, transplantation of corrected hepatocytes would correct for disease symptoms. Liver donor shortage and hepatocyte inability to proliferate in vitro accentuate this problem. Embryonic stem an ...
2010Tissue engineering of the bladder
Stem cell use in bladder tissue engineering is a recently addressed area of investigation that has generated excitement as a novel way to restore and regenerate lost or damaged urinary bladder tissue. The remodelling of smooth muscle plays a significant ro ...
EPFL2009Aggravation of viral hepatitis by platelet-derived serotonin
More than 500 million people worldwide are persistently infected with hepatitis B virus or hepatitis C virus. Although both viruses are poorly cytopathic, persistence of either virus carries a risk of chronic liver inflammation, potentially resulting in li ...
2008