Publication
Half a century of amyloids: past, present and future
Related publications (67)
Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance
Microglial cells aggregate around amyloid plaques in Alzheimer's disease, but, despite their therapeutic potential, various aspects of their reactive kinetics and role in plaque pathogenesis remain hypothetical. Through use of in vivo imaging and quantitat ...
Society for Neuroscience2008A beta 42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
We have generated a novel transgenic mouse model on a C57BL/ 6J genetic background that coexpresses KM670/ 671NL mutated amyloid precursor protein and L166P mutated presenilin 1 under the control of a neuron- specific Thy1 promoter element ( APPPS1 mice). ...
Nature Publishing Group2006Switch peptides
Incorrect folding of proteins, leading to aggregation and amyloid formation, is associated with a group of degenerative diseases including Alzheimer's disease and late onset diabetes. Amyloid forming proteins are believed to be mainly α-helical in their na ...
EPFL2006Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes
László Forró, Aleksandra Radenovic, Andras Kis
The pathological hallmarks of Alzheimer's disease (AD) consist of P-amyloid plaques and neurofibrillary tangles in affected brain areas. The processes, which drive this host reaction are unknown. To determine whether an analogous host reaction to that occu ...
Elsevier2006In vitro preparation of prefibrillar intermediates of amyloid-beta and alpha-synuclein
Elucidating the structural properties of early intermediates (protofibrils) on the fibril formation pathway of Abeta and alpha-synuclein, the structural relationship among the different intermediates and their relationship to the structure of the amyloid f ...
Humana Press2005Amyloid fibril formation by macrophage migration inhibitory factor
We demonstrate herein that human macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine expressed in the brain and not previously considered to be amyloidogenic, forms amyloid fibrils similar to those derived from the disease associated ...
Elsevier2005Hydration and packing are crucial to amyloidogenesis as revealed by pressure studies on transthyretin variants that either protect or worsen amyloid disease
The formation of amyloid aggregates is the hallmark of the amyloidogenic diseases. Transthyretin (TTR) is involved in senile systemic amyloidosis (wild-type protein) and familial amyloidotic polyneuropathy (point mutants). Through the use of high hydrostat ...
Elsevier2003Pharmacological profiles of peptide drug candidates for the treatment of Alzheimer's disease
Amyloid plaques in brain, composed of aggregates of amyloid-beta peptide, play a central role in the pathogenesis of Alzheimer's disease and represent a good target for treatment. We have shown previously that a 5-amino acid beta-sheet breaker peptide (iAb ...
2003Apomorphine inhibitors of amyloid-beta (abeta) fibril formation and their use in amyloidosis based disease
Described is a new class of small molecule inhibitors of amyloid beta protein (Abeta) aggregation, based on apomorphine. These molecules target the nucleation phase of Abeta self-assembly and interfere effectively with aggregation of Abeta 1-40 into amyloi ...
2003hA molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization
Hilal Lashuel, Sabrina Susan Vollers
Aberrant protein oligomerization is an important pathogenetic process in vivo. In Alzheimer's disease (AD), the amyloid beta-protein (Abeta) forms neurotoxic oligomers. The predominant in vivo Abeta alloforms, Abeta40 and Abeta42, have distinct oligomeriza ...
American Chemical Society2003