Measurement of metabolic changes in acute doxorubicin-induced cardiotoxicity in mice using hyperpolarized [1-13C]pyruvate
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Cardiac and skeletal muscle function relies on a continuous energy production via fatty acid metabolism and mitochondrial oxidation of pyruvate, with a fine balance between substrate delivery and utilization. Changes in metabolism are increasingly being im ...
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In this work we present numerical simulations of continuous flow left ventricle assist device implantation with the aim of comparing the ascending and the descending aorta anastomosis of outflow cannula. Despite the fact that the second approach is less in ...
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Pluripotent stem cell-seeded cardiopatches hold promise for in situ regeneration of infarcted hearts. Here, we describe a novel cardiopatch based on bone morphogenetic protein 2-primed cardiac-committed mouse embryonic stem cells, embedded into biodegradab ...
In this thesis we study ventricular-arterial coupling in rodents under the influence of arterial stiffening and myocardial infarction (MI), combination of the two considered as a novel cardiovascular research model for diseased hearts pumping against an ag ...