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Publication
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Work with us on data science and visualisation projects, and deploy your project as an app on top of Graph Search.
D-amino acid oxidase (DAO) is an enzyme that catalyzes the degradation of D-amino acids in the body. Here, we explored the possibility of detecting D-amino acid oxidase activity by monitoring its metabolism in the rat kidney after a bolus injection of hyperpolarized D-[1-13C]alanine. Our data show that D-alanine is readily converted to lactate only when the DAO enzyme is not inhibited, indicating that the observed metabolism is that of DAO.
Christophe Marcel Georges Galland, Valeria Vento, Sachin Suresh Verlekar, Philippe Andreas Rölli
Katie Sabrina Catherine Rosie Marsden
Brice Tanguy Alphonse Lecampion, Andreas Möri