Publications related to Reconstruction Methods for Cryo-Electron Microscopy: From Model-based to Data-driven

Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes

Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain protein implicated in the pathogenesis of both familial and sporadic Parkinson's disease (PD), and currently one of the most promising therapeutic targets for drug design in Parkinson's disease. I ...

Springer Nature2017

Stereo-vision three-dimensional reconstruction of curvilinear structures imaged with a TEM

Pascal Fua, Cécile Hébert, Marco Cantoni, Emad Oveisi, Guillaume Lucas, Antoine Letouzey, Sandro Ivo Sebastiano De Zanet

Deriving accurate three-dimensional (3-D) structural information of materials at the nanometre level is often crucial for understanding their properties. Tomography in transmission electron microscopy (TEM) is a powerful technique that provides such inform ...

Elsevier2017

Blotting-free and lossless cryo-electron microscopy grid preparation from nanoliter-sized protein samples and single-cell extracts

Henning Paul-Julius Stahlberg, Anastasia Syntychaki

We present a sample preparation method for cryo-electron microscopy (cryo-EM) that requires only 320 nL of sample to prepare a cryo-EM grid, depending on the protocol used. The sample is applied and spread on the grid by a microcapillary. The procedure doe ...

Elsevier BV2017

Compressed sensing for STEM tomography

Michaël Unser, Laurène Donati, Masih Nilchian

A central challenge in scanning transmission electron microscopy (STEM) is to reduce the electron radiation dosage required for accurate imaging of 3D biological nano-structures. Methods that permit tomographic reconstruction from a reduced number of STEM ...

2017

Three-dimensional electron imaging of dislocations from a single sample tilt

Pascal Fua, Cécile Hébert, Emad Oveisi, Antoine Letouzey

Linear crystal defects called dislocations are one of the most fascinating concepts in materials science that govern mechanical and optoelectronic properties of many materials across a broad range of application. Three-dimensional (3-D) study of dislocatio ...

Wiley2016

Cryo-electron microscopy of membrane proteins

Henning Paul-Julius Stahlberg

Electron crystallography is used to study membrane proteins in the form of planar, two-dimensional (2D) crystals, or other crystalline arrays such as tubular crystals. This method has been used to determine the atomic resolution structures of bacteriorhodo ...

Humana Press2013

Rapid Access to Polyfunctional Lipids with Complex Architecture via Oxyanionic Ring-Opening Polymerization

Frederik Roman Wurm

Polymer-coated liposomes, particularly poly(ethylene glycol) (PEG)-substituted liposomes, have emerged as long-circulating carrier systems for drug delivery and diagnostic purposes. A rapid synthesis of three different types of multifunctional lipids with ...

American Chemical Society2011

An optical and microPET assessment of thermally-sensitive liposome biodistribution in the Met-1 tumor model: Importance of formulation

Henning Paul-Julius Stahlberg, Hua Zhang, Jin Won Seo

The design of delivery vehicles that are stable in circulation but can be activated by exogenous energy sources is challenging. Our goals are to validate new imaging methods for the assessment of particle stability, to engineer stable and activatable parti ...

Elsevier BV2010

On Random Tomography with Unobservable Projection Angles

Victor Panaretos

We formulate and investigate a statistical inverse problem of a random tomographic nature, where a probability density function on

\mathbb{R}^3

is to be recovered from observation of finitely many of its two-dimensional projections in random and unobserv ...

Institute of Mathematical Statistics2009

Non-180° domains in LiTaO3 thin films deposited by metal organic chemical vapor deposition

Nava Setter

Epitaxial lithium tantalate (LiTaO3) thin films were grown on the hexagonal plane of sapphire substrates by metal organic chemical vapor deposition. Two crystallographic variants, related to each other by 180° rotation around the c axis, as well as non-180 ...

2009

Reconstruction Methods for Cryo-Electron Microscopy: From Model-based to Data-driven

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Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes

Stereo-vision three-dimensional reconstruction of curvilinear structures imaged with a TEM

Blotting-free and lossless cryo-electron microscopy grid preparation from nanoliter-sized protein samples and single-cell extracts

Compressed sensing for STEM tomography

Three-dimensional electron imaging of dislocations from a single sample tilt

Cryo-electron microscopy of membrane proteins

Rapid Access to Polyfunctional Lipids with Complex Architecture via Oxyanionic Ring-Opening Polymerization

An optical and microPET assessment of thermally-sensitive liposome biodistribution in the Met-1 tumor model: Importance of formulation

On Random Tomography with Unobservable Projection Angles

Non-180° domains in LiTaO3 thin films deposited by metal organic chemical vapor deposition

Cryo-electron microscopy of membrane proteins

Non-180° domains in LiTaO3 thin films deposited by metal organic chemical vapor deposition

Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes

Blotting-free and lossless cryo-electron microscopy grid preparation from nanoliter-sized protein samples and single-cell extracts

Compressed sensing for STEM tomography

Three-dimensional electron imaging of dislocations from a single sample tilt

Stereo-vision three-dimensional reconstruction of curvilinear structures imaged with a TEM

An optical and microPET assessment of thermally-sensitive liposome biodistribution in the Met-1 tumor model: Importance of formulation

Rapid Access to Polyfunctional Lipids with Complex Architecture via Oxyanionic Ring-Opening Polymerization

On Random Tomography with Unobservable Projection Angles