Publication
Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations
Related publications (36)
Influence of DNP Polarizing Agents on Biochemical Processes: TEMPOL in Transient Ischemic Stroke
Mor-Miri Mishkovsky, Jean-Noël Hyacinthe, Mario Gaetano Lepore, Thanh Phong Kevin Lê, Lara Buscemi Estefanell
Hyperpolarization of 13C by dissolution dynamic nuclear polarization (dDNP) boosts the sensitivity of magnetic resonance spectroscopy (MRS), making possible the monitoring in vivo and in real time of the biochemical reactions of exogenously infused 13C-lab ...
2023Late post‐natal neurometabolic development in healthy male rats using 1 H and 31 P Magnetic Resonance Spectroscopy
Rolf Gruetter, Cristina Ramona Cudalbu, Dunja Simicic, Veronika Rackayová, Guillaume Donati
Brain metabolism evolves rapidly during early post‐natal development in the rat. While changes in amino acids, energy metabolites, antioxidants or metabolites involved in phospholipid metabolism have been reported in the early stages, neurometabolic change ...
2021Brain metabolism during Chronic Hepatic Encephalopathy studied by in vivo 1H and 31P MRS
Magnetic resonance spectroscopy (MRS) is a powerful tool increasingly used in biomedical research and also in clinical practice.
This thesis focused on the improvements of in vivo 31P MRS and 31P magnetization transfer methods at high magnetic field (9.4T ...
EPFL2018Study of cortical energy metabolism during sensory stimulation-induced brain activity by ¹³C magnetic resonance spectroscopy in vivo
Cerebral function is associated with high metabolic activity that is supported by continuous supply of oxygen and glucose from the blood. Coupling between brain energy metabolism and neuronal activity has been studied extensively during the past decades. N ...
EPFL2017Progress towards in vivo brain (13)C-MRS in mice: Metabolic flux analysis in small tissue volumes
Rolf Gruetter, Bernard Lanz, Marta Lai
The combination of dynamic (13)C MRS data under infusion of (13)C-labeled substrates and compartmental models of cerebral metabolism enabled in vivo measurement of metabolic fluxes with a quantitative and distinct determination of cellular-specific activit ...
Elsevier2017How Energy Metabolism Supports Cerebral Function: Insights from 13C Magnetic Resonance Studies In vivo
Rolf Gruetter, João Miguel das Neves Duarte, Sarah Catherine Sonnay
Cerebral function is associated with exceptionally high metabolic activity, and requires continuous supply of oxygen and nutrients from the blood stream. Since the mid-20th century the idea that brain energy metabolism is coupled to neuronal activity has e ...
Frontiers Research Foundation2017Lactoferrin during lactation reduces lipopolysaccharide-induced brain injury
Lactoferrin (Lf), component of maternal milk, has antioxidant, anti-inflammatory and antimicrobial properties. Neuroprotective effects of Lf on the immature brain have been recently shown in rodent models of intrauterine growth restriction and cerebral hyp ...
Wiley-Blackwell2016Measuring changes in substrate utilization in the myocardium in response to fasting using hyperpolarized [1-(13)C]butyrate and [1-(13)C]pyruvate
Arnaud Comment, Josefina Adriana Maria Bastiaansen
Cardiac dysfunction is often associated with a shift in substrate preference for ATP production. Hyperpolarized (HP) (13)C magnetic resonance spectroscopy (MRS) has the unique ability to detect real-time metabolic changes in vivo due to its high sensitivit ...
2016High precision trajectory and speed sensor and measuring method
Kamiar Aminian, Benedikt Fasel
A method for contactlessly determining an exact passage of an athlete at points placed along a track in sports, wherein the method comprises gearing the athlete with a wearable magnetometer sensor unit, whereby the magnetometer sensor unit is equipped with ...
2016Assessment of metabolic fluxes in the mouse brain in vivo using (1)H-[(13)C] NMR spectroscopy at 14.1 Tesla
Rolf Gruetter, Lijing Xin, Hongxia Lei, Bernard Lanz
(13)C magnetic resonance spectroscopy (MRS) combined with the administration of (13)C labeled substrates uniquely allows to measure metabolic fluxes in vivo in the brain of humans and rats. The extension to mouse models may provide exclusive prospect for t ...
Nature Publishing Group2015