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Computational pipeline to probe NaV1.7 gain-of-function variants in neuropathic painful syndromes

Related publications (32)

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Towards an Understanding of Hydraulic Sensitivity: Graph Theory Contributions to Water Distribution Analysis

Jérôme Chenal

Water distribution systems (WDSs) are complex networks with numerous interconnected junctions and pipes. The robustness and reliability of these systems are critically dependent on their network structure, necessitating detailed analysis for proactive leak ...

Basel2024

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Maximal subgraph mining is increasingly important in various domains, including bioinformatics, genomics, and chemistry, as it helps identify common characteristics among a set of graphs and enables their classification into different categories. Existing ...

ELSEVIER SCIENCE INC2023

In the beginning was the metabolism. The biochemical processes that make life possible transformed the soup of chemicals into the life on Earth we know today. Since then, living organisms have evolved, and life on Earth has become more complex. Living orga ...

EPFL2023

Space-Efficient Representations of Graphs

Jakab Tardos

With the increasing prevalence of massive datasets, it becomes important to design algorithmic techniques for dealing with scenarios where the input to be processed does not fit in the memory of a single machine. Many highly successful approaches have emer ...

EPFL2022

Unambiguous DNFs and Alon-Saks-Seymour

Mika Tapani Göös, Siddhartha Jain

We exhibit an unambiguous k-DNF formula that requires CNF width (Omega) over tilde (k(2)), which is optimal up to logarithmic factors. As a consequence, we get a near-optimal solution to the Alon-Saks-Seymour problem in graph theory (posed in 1991), which ...

IEEE COMPUTER SOC2022

Intracellular recording of cardiomyocyte action potentials with nanopatterned volcano-shaped microelectrodes

Benoît Xavier Emmanuel Desbiolles

Micro-nanotechnology based multielectrode arrays have led to remarkable progress in the field of transmembrane voltage recordings of excitable cells. However, electrode geometries alone have failed to produce a cell-electrode interface that is sufficiently ...

EPFL2020

GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons

Sean Lewis Hill, Christian Andreas Rössert, Bas-Jan Zandt, Steven Petrou

The binding of GABA (gamma-aminobutyric acid) to extrasynaptic GABA(A) receptors generates tonic inhibition that acts as a powerful modulator of cortical network activity. Despite GABA being present throughout the extracellular space of the brain, previous ...

NATL ACAD SCIENCES2020

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Graphs are extensively used to represent networked data. In many applications, especially when considering large datasets, it is a desirable feature to focus the analysis onto specific subgraphs of interest. Slepian theory and its extension to graphs allow ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Intracellular Recording of Cardiomyocyte Action Potentials with Nanopatterned Volcano-Shaped Microelectrode Arrays

Philippe Renaud, Arnaud Bertsch, Benoît Xavier Emmanuel Desbiolles

Micronanotechnology-based multielectrode ar- rays have led to remarkable progress in the field of transmembrane voltage recording of excitable cells. However, providing long-term optoporation- or electroporation-free intracellular access remains a consider ...

2019

This paper studies sufficient conditions to obtain efficient distributed algorithms coloring graphs optimally (i.e. with the minimum number of colors) in the LOCAL model of computation. Most of the work on distributed vertex coloring so far has focused on ...

SCHLOSS DAGSTUHL, LEIBNIZ CENTER INFORMATICS2019