Publication
System for closed loop control of autonomic function
Related publications (34)
Novel theory and potential applications of central diastolic pressure decay time constant
Nikolaos Stergiopoulos, Georgios Rovas, Sokratis Anagnostopoulos, Vasiliki Bikia, Patrick Segers
Central aortic diastolic pressure decay time constant ( ) is according to the two-element Windkessel model equal to the product of total peripheral resistance (R) times total arterial compliance (C ). As such, it is related to arterial stiffness, which has ...
2024Modulation of Pulsatile Left Ventricular Afterload by Renal Denervation in Heart Failure With Preserved Ejection Fraction
Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou
Background:Arterial stiffening contributes to hemodynamic derangements in heart failure with preserved ejection fraction (HFpEF). We sought to investigate the impact of renal denervation on pulsatile left ventricular loading in patients with HFpEF and hype ...
Philadelphia2023Validation of a Non-invasive Inverse Problem-Solving Method for Stroke Volume
Nikolaos Stergiopoulos, Georgios Rovas, Vasiliki Bikia, Stamatia Zoi Pagoulatou, Emma Marie Roussel
Stroke volume (SV) is a major biomarker of cardiac function, reflecting ventricular-vascular coupling. Despite this, hemodynamic monitoring and management seldomly includes assessments of SV and remains predominantly guided by brachial cuff blood pressure ...
FRONTIERS MEDIA SA2022Implanted System for Orthostatic Hypotension in Multiple-System Atrophy
Grégoire Courtine, Jocelyne Bloch, Jordan Squair, Léonie Asboth, Robin Jonathan Demesmaeker, Nicolas Hankov, Sergio Daniel Hernandez, Grégory Didier Dumont, Suje Amir, Maxime Berney
Orthostatic hypotension is a cardinal feature of multiple-system atrophy. The upright posture provokes syncopal episodes that prevent patients from standing and walking for more than brief periods. We implanted a system to restore regulation of blood press ...
MASSACHUSETTS MEDICAL SOC2022Longitudinal interrogation of sympathetic neural circuits and hemodynamics in preclinical models
Grégoire Courtine, Quentin Barraud, Jordan Squair, Matthieu Pierre Gautier, Rémi Bernard René Hudelle, Suje Amir, Victor Perez Puchalt, Loïs Thomas Romain Mahe, Jan Elaine Cuevas Soriano
Neurological disorders, including spinal cord injury, result in hemodynamic instability due to the disruption of supraspinal projections to the sympathetic circuits located in the spinal cord. We recently developed a preclinical model that allows the ident ...
NATURE PORTFOLIO2022Electrical spinal cord stimulation protocols to regulate neurological functions after spinal cord injury
Spinal cord injury (SCI) is a life-changing event. People who suffer from it lose their abilityto move normally and are subject to life-threatening symptoms. When the insult is not toosevere, partial recovery is possible. Otherwise, for severely affected p ...
EPFL2021Implantable blood pressure monitor
Grégoire Courtine, Jordan Squair
An implantable blood pressure monitor has two or more elements configured to wrap at least part way around a blood vessel. Changes in pressure within the blood vessel may be sensed by detecting movements of the elements or forces applied to the elements. A ...
2021System and method for control of autonomic function
Grégoire Courtine, Jordan Squair
A system (10) for neuromodulation and/or neurostimulation, for the treatment of a mammal, at least comprising: - at least one control unit (12) configured and arranged to provide stimulation data; - at least one stimulation unit (14) configured and arrange ...
2020Hemodynamics of ageing, ventricular-arterial coupling and noninvasive assessment of key hemodynamical and cardiac quantities
Ageing is a natural process that affects both the anatomical and functional properties of the cardiovascular system and alters the coupling characteristics between the heart and the aorta. These alterations may predispose the cardiovascular system in the d ...
EPFL2020Dual-responsive polyphosphazene as a common platform for highly efficient drug self-delivery
For clinical applications, simplicity, high efficiency, and low toxicity are key issues in the design of anti-tumor drugs. In this work, a novel dual-responsive drug self-framed delivery system (DSFDS) with high drug delivery efficiency is proposed based o ...
2019