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Designs and Characterization of Subunit Ebola GP Vaccine Candidates: Implications for Immunogenicity
Related publications (44)
A Nanoscaffolded Spike-RBD Vaccine Provides Protection against SARS-CoV-2 with Minimal Anti-Scaffold Response
David Hacker, Bruno Emanuel Ferreira De Sousa Correia, Florence Pojer, Kelvin Ka Ching Lau
The response of the adaptive immune system is augmented by multimeric presentation of a specific antigen, resembling viral particles. Several vaccines have been designed based on natural or designed protein scaffolds, which exhibited a potent adaptive imm ...
2021Enhancing daily light exposure increases the antibody response to influenza vaccination in patients with dementia
Jean-Louis Scartezzini, Mirjam Münch
Enhancing lighting conditions in institutions for individuals with dementia improves their sleep, circadian rhythms and well-being. Here, we tested whether a greater long-term daily light exposure supports the immune response to the annual influenza vaccin ...
Cold Spring Harbor Laboratory Press2020Rationally designed Human Cytomegalovirus gB nanoparticle vaccine with improved immunogenicity
Author summary Human cytomegalovirus (HCMV) infection is the foremost viral cause of congenital birth defects. Attempts to vaccinate against HCMV brought moderate, though not sufficient, reduction in infection. Moreover, phase II clinical trial with gB for ...
PUBLIC LIBRARY SCIENCE2020HLA tapasin independence: broader peptide repertoire and HIV control
Human leukocyte antigen (HLA) class I allotypes vary in their ability to present peptides in the absence of tapasin, an essential component of the peptide loading complex. We quantified tapasin dependence of all allotypes that are common in European and Af ...
NATL ACAD SCIENCES2020Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study
Didier Trono, Idris Guessous, Benjamin André René Meyer, David Nicolas De Ridder, Dusan Petrovic
Assessing the burden of COVID-19 on the basis of medically attended case numbers is suboptimal given its reliance on testing strategy, changing case definitions, and disease presentation. Population-based serosurveys measuring anti-severe acute respiratory ...
2020Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen
Bruno Emanuel Ferreira De Sousa Correia, Pablo Gainza Cirauqui, Jaume Bonet Martinez, Sai Reddy, Fabian Sesterhenn, Stéphane Rosset, Che Yang, Patricia Corthésy Henrioud, Sabrina Susan Vollers
Throughout the last several decades, vaccination has been key to prevent and eradicate infectious diseases. However, many pathogens (e.g., respiratory syncytial virus [RSV], influenza, dengue, and others) have resisted vaccine development efforts, largely ...
2019Genetic determinants of healthy human immune variance: from humoral response to microbiome diversity
Identifying the drivers of the observed interindividual variability of the human immune system is crucial to our understanding of infectious and immune-mediated diseases. The contribution of genetic and non-genetic factors to immunological differences betw ...
EPFL2018Development of a nano-adjuvant cancer vaccine and its evaluation for melanoma in combination with radiotherapy
Cancer is the second leading cause of death in the world and melanoma is the deadliest type of skin cancer. Although surgery, radiotherapy and chemotherapy are still standard treatments, the discovery of the role played by the immune system in cancer has a ...
EPFL2018Evaluation of oxidation-sensitive polymersomes as vaccine nanocarriers to enhance humoral responses against arenavirus envelope glycoproteins
Vaccines currently represent one of the most effective means to control and prevent infectious diseases affecting humans and animals and have dramatically improved public health, quality of life, and life expectancy. Over the last years several conceptual ...
EPFL2017Oxidation-sensitive polymersomes as vaccine nanocarriers enhance humoral responses against Lassa virus envelope glycoprotein
Marcela Rincón-Restrepo, Jeffrey Alan Hubbell, Melody Swartz, Sachiko Hirosue, Clara Galan Navarro, Stefan Kunz
Lassa virus (LASV) causes severe hemorrhagic fever with high mortality, yet no vaccine currently exists. Antibodies targeting viral attachment proteins are crucial for protection against many viral infections. However, the envelope glycoprotein (GP) 1 of L ...
Academic Press Inc Elsevier Science2017