Publication

Where Electrophile Signaling and Covalent Ligand-Target Mining Converge

Yimon Aye
2020
Journal paper

Abstract

Interests in learning how to engineer most effective covalent ligands, identify novel functional targets, and define precise mechanism-of-action are rapidly growing in both academia and pharmaceutical industries. We here illuminate the establishment of a multifunctional platform that offers new capabilities to logically engineer covalent ligands and dissect 'on-target' bioactivity with precise biological context and precision hitherto inaccessible. Broadly aimed at non-specialist readers, this opinion piece is aimed to stoke the interest of emerging chemists and biologists/bioengineers, but the underlying technological and conceptual topicality is anticipated to also appeal to experts leading ligand-target mining, validation, and -discovery research programs.

Official source

https://infoscience.epfl.ch/record/282268?ln=en

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