TunicateA tunicate is a marine invertebrate animal, a member of the subphylum Tunicata (ˌtjuːnᵻˈkeɪtə ). It is part of the Chordata, a phylum which includes all animals with dorsal nerve cords and notochords (including vertebrates). The subphylum was at one time called Urochordata, and the term urochordates is still sometimes used for these animals. They are the only chordates that have lost their myomeric segmentation, with the possible exception of the 'seriation of the gill slits'.
Geochemical cycleIn Earth science, a geochemical cycle is the pathway that chemical elements take in the surface and crust of the Earth. The term "geochemical" tells us that geological and chemical factors are all included. The migration of heated and compressed chemical elements and compounds such as silicon, aluminium, and general alkali metals through the means of subduction and volcanism is known in the geological world as geochemical cycles. The geochemical cycle encompasses the natural separation and concentration of elements and heat-assisted recombination processes.
Buprenorphine/naloxoneBuprenorphine/naloxone, sold under the brand name Suboxone among others, is a fixed-dose combination medication that includes buprenorphine and naloxone. It is used to treat opioid use disorder, and reduces the mortality of opioid use disorder by 50% (by reducing the risk of overdose on full-agonist opioids such as heroin or fentanyl). It relieves cravings to use and withdrawal symptoms. Buprenorphine/naloxone is available for use in two different forms, under the tongue or in the cheek.
BuprenorphineBuprenorphine, sold under the brand name Subutex among others, is an opioid used to treat opioid use disorder, acute pain, and chronic pain. It can be used under the tongue (sublingual), in the cheek (buccal), by injection (intravenous and subcutaneous), as a skin patch (transdermal), or as an implant. For opioid use disorder, it is typically started when withdrawal symptoms have begun and for the first two days of treatment under direct observation of a health-care provider.
4.2-kiloyear eventThe 4.2-kiloyear (thousand years) BP aridification event (long-term drought) was one of the most severe climatic events of the Holocene epoch. It defines the beginning of the current Meghalayan age in the Holocene epoch. Starting around 2200 BC, it probably lasted the entire 22nd century BC. It has been hypothesised to have caused the collapse of the Old Kingdom in Egypt as well as the Akkadian Empire in Mesopotamia, and the Liangzhu culture in the lower Yangtze River area.
