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A partially self-regenerating synthetic cell

Related publications (32)

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Engineering chromatin states: Chemical and synthetic biology approaches to investigate histone modification function

Beat Fierz, Horst Pick, Sinan Kilic

Patterns of histone post-translational modifications (PTMs) and DNA modifications establish a landscape of chromatin states with regulatory impact on gene expression, cell differentiation and development. These diverse modifications are read out by effecto ...

Elsevier Science Bv2014

Structural Studies and Protein Engineering of Human O6-Alkylguanine-DNA Alkyltransferase

Birgit Mollwitz

The specific labeling of proteins with synthetic probes is a powerful approach to study protein function and protein tags have been widely used for this purpose. A well-established example for a self-labeling protein tag is SNAP-tag. It specifically reacts ...

EPFL2012

The commercial application of biosensors has had a significant impact in a number of areas, particularly in the field of medical diagnostics. But in spite of the great number of publications, only a few systems are commercially available in food analysis. ...

EPFL2009

Tissue engineering of the bladder

Catharina Adelöw

Stem cell use in bladder tissue engineering is a recently addressed area of investigation that has generated excitement as a novel way to restore and regenerate lost or damaged urinary bladder tissue. The remodelling of smooth muscle plays a significant ro ...

EPFL2009

Chemical approaches to microarrays and multifunctional protein labeling

India Christina Sielaff

With the human genome and many other eukaryotic and procaryotic genomes sequenced, the interest in life sciences is shifting towards the examination of the function, modification and regulation of the encoded proteins. Proteins are involved in virtually al ...

EPFL2006

A review with twenty-nine refs. on the authors' current research. Protein design and mimicry combines elements of synthetic org. chem. with structural and functional aspects of biol. relevance in a unique way. Due to progress in this interdisciplinary rese ...

2000

Extending the concept of template-assembled synthetic proteins

A review with 56 refs. The creation of native-like macromols. in copying nature's way represents a fascinating challenge in protein chem. today. In the absence of detailed knowledge of the complex folding pathway, the ultimate goal in protein de novo desig ...

1999

A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins

Philipp Bucher

Computer analysis of a conserved domain, BRCT, first described at the carboxyl terminus of the breast cancer protein BRCA1, a p53 binding protein (53BP1), and the yeast cell cycle checkpoint protein RAD9 revealed a large superfamily of domains that occur p ...

1997

Protein de novo design

A review with 43 refs. on strategies for the synthesis of protein mimetics and artificial proteins. The ultimate goal in protein de novo design is the construction of artificial proteins inhibiting tailor-made structural and functional properties. To creat ...

1996

Role of cysteine62 in DNA recognition by the p50 subunit of NF-kappa B

Gerardo Turcatti

A powerful chemical modification procedure has been developed to define determinants of DNA recognition by the p50 subunit of NF-kappa B. Differential labelling with [14C] iodoacetate has identified a conserved cysteine residue, Cys62, that was protected f ...

1993