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A photoredox-catalyzed oxidative decarboxylative coupling of small peptides is reported, giving access to a variety of N,O-acetals. They were used as intermediates for the addition of phenols and indoles, leading to novel peptide scaffolds and bioconjugates. Amino acids with nucleophilic side chains, such as serine, threonine, tyrosine and tryptophan, could also be used as partners to access tri- and tetrapeptide derivatives with non-natural cross-linking.
Jérôme Waser, Christine Alice Jacqueline Marty, Emmanuelle Madeline Dominique Allouche
Tamar Kohn, Aleksandar Antanasijevic, Kiruthika Kumar, Shotaro Torii
Nako Nakatsuka, Xinyu Zhang, Haiying Hu