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The control of gut homeostasis by autophagy in the context of host-microbiota relationship remains poorly understood. In this issue of Developmental Cell, Nagai et al. (2021) show that autophagy plays a crucial role in enterocytes to prevent the mis-regulation of the Hippo-Yorkie pathway by the microbiota.
Hilal Lashuel, Florian Lang, Joan Romani Aumedes, Yogesh Singh