Akt Is S-Palmitoylated: A New Layer of Regulation for Akt
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Adipose tissue is a key metabolic and highly-dynamic organ whose dysregulation may cause clinical conditions of concern such as obesity and lipodystrophy. Its function varies based on the anatomy, in fact, visceral adipose tissue expansion carries a greate ...
White adipose tissue (WAT) is a cellularly heterogeneous endocrine organ that not only serves as a reservoir for storing and releasing energy but also actively participates in metabolic homeostasis. Given the current rise in obesity and its associated com ...
Cell-to-cell variability plays a key role in tissue patterning by setting initial asymmetry that primes cell fate decisions. Fluctuations in the activity of regulatory molecules can commit individual cells to divergent differentiation pathways, and cell-to ...
The bone marrow (BM) microenvironment, or niche, significantly affects behaviors of its resident stem cell populations. Disruptions in the BM niche contribute to a number of severe clinical pathologies. Discovery of novel therapeutic strategies for BM-rela ...
Cells are the smallest operational units of living systems. Through synthesis of various biomolecules and exchange of signals with the environment, cells tightly regulate their composition to realize a specific functional state. The transformation of a cel ...
This conversation focuses on the work of Sarah Kenderdine and Merete Sanderhoff, both of whom are based in Europe working on and within museums, as well as playing leadership roles in pan-institutional organisations such as Europeana and the Australasian A ...
Routledge2020
The design process is a series of endeavors aimed to solve a problem, which is extensively defined as a need, a task, a situation, etc. Visualizations are objects that result from a design process that solves a problem of unreadable data. They are technica ...
Hematopoietic stem cells (HSC) are responsible for the life-long maintenance of our blood system. Their long-term capacity to both self-renew and differentiate and the ability to efficiently âhomeâ to their bone marrow niches when injected in the blood ...
Entry of the facultative intracellular pathogen Brucella into host cells results in the formation of endosomal Brucella-containing vacuoles (eBCVs) that initially traffic along the endocytic pathway. eBCV acidification triggers the expression of a type IV ...
The Company of Biologists2018
Embryonic stem (ES) cells have the capacity to give rise to all cell types of the adult organism and can be used as a model to study early cell fate decisions as they closely recapitulate in vivo events. The M and G1 phases have been suggested to be the ke ...
