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Statistical physics of periodic biological processes

Lorenzo Talamanca

Earth rotation around its axis imposes a 24-hour rhythmicity to all life on the planet.Rather than passively responding to these periodic changes, nature has given us an internal timekeeper, the circadian clock, to anticipate to our advantage the fluctuati ...

EPFL2023

Sex-dimorphic and age-dependent organization of 24-hour gene expression rhythms in humans

Felix Naef, Cédric Gobet, Lorenzo Talamanca

The circadian clock modulates human physiology. However, the organization of tissue-specific gene expression rhythms and how these depend on age and sex is not defined in humans. We combined data from the Genotype-Tissue Expression (GTEx) project with an a ...

AMER ASSOC ADVANCEMENT SCIENCE2023

The circadian clock time tunes axonal regeneration

Thomas Haynes Hutson

Nerve injuries cause permanent neurological disability due to limited axonal regeneration. Injury-dependent and-independent mechanisms have provided important insight into neuronal regeneration, however, common denominators underpinning regeneration remain ...

Cambridge2023

VELUX Build for Life

Marilyne Andersen

In this video, Prof. Marilyne Andersen discusses the many benefits, challenges, promises and ongoing research on daylighting as an essential part of our daily life. The podcast addresses questions of design, comfort, resource efficiency and health by divin ...

2022

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The ipRGCs in the human eye mediate several effects on people, such as alertness and circadian rhythms. The spectral, temporal and spatial characteristics of light influence the magnitude of these effects. To facilitate the anticipation of the ipRGC-influe ...

2022

Human circadian rhythms and urban density: celebrating the natural day-night cycle

Marilyne Andersen, Mark Pauly, Florin Isvoranu, Megan Nicole Danell, Javier Fernandez Contreras

Our exposure to light has a key role in regulating our biological clock through a dedicated photoreceptor present in the human eye. Increased awareness to its criticality when it comes to human well-being is urgently needed, as this criticality is potentia ...

SoomeenHahm Design Ltd2021

Modeling synchronization in globally coupled oscillatory systems using model order reduction

Jan Sickmann Hesthaven, Niccolo' Discacciati

We construct reduced order models for two classes of globally coupled multi-component oscillatory systems, selected as prototype models that exhibit synchronization. These are the Kuramoto model, considered both in its original formulation and with a suita ...

AIP Publishing2021

Dealing with Daily Rhythms: Families’ Strategies to Tackle Chronic Time Pressure

Vincent Kaufmann, Guillaume Simon Joseph Drevon, Philippe Gerber

As suggested by the conservation of resources theory, in contemporary societies time is considered as a limited resource in the same way as money and energy. In the current paper, a novel daily rhythm approach related to motility is presented, in order to ...

2020

Tissue-specific circadian transcriptional regulation

Jake Yeung

Circadian rhythms in physiology and behavior evolved to resonate with daily cycles in the external environment. In mammals, organs orchestrate temporal physiology over the 24-hour day, which requires extensive gene expression rhythms targeted to the right ...

EPFL2019

The circadian clock is a molecular endogenous timekeeping system and allows organisms to adjust their physiology and behavior to the geophysical time. Organized hierarchically, the master clock in the suprachiasmatic nuclei, coordinates peripheral clocks, ...

WILEY2019