Publication
Dual proteomics of Drosophila melanogaster hemolymph infected with the heritable endosymbiont Spiroplasma poulsonii
Related publications (37)
BRB-seq: ultra-affordable high-throughput transcriptomics enabled by bulk RNA barcoding and sequencing
Bart Deplancke, David Hacker, Bastien Mangeat, Vincent Roland Julien Gardeux, Julie Marie Russeil, Daniel Alpern, Antonio Carlos Alves Meireles Filho
Despite its widespread use, RNA-seq is still too laborious and expensive to replace RT-qPCR as the default gene expression analysis method. We present a novel approach, BRB-seq, which uses early multiplexing to produce 3 cDNA libraries for dozens of sample ...
2019The double-edged toxins
Many insect species are associated with endosymbiotic bacteria which have the particularity of living within host tissues. Endosymbionts benefit from this stable and nutritious environment, while providing ecological advantages to their host, such as prote ...
EPFL2018Mitochondrial stress signalling and its impacts on physiology
Adrienne Joëlle Laurence Mottis
Mitochondria are responsible for respiration and energy harvesting across the eukaryotic kingdom. They also take part in other cellular processes like intermediary metabolism. As a result, mitochondrial function directly impacts organismal features such as ...
EPFL2018Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population
Johan Auwerx, Jun Yong Kim, Dongryeol Ryu, Evan Graehl Williams, Pooja Jha, Jiayi Lan, Ruedi Aebersold, Moaraj Hasan
We have used SWATH mass spectrometry to quantify 3648 proteins across 76 proteomes collected from genetically diverse BXD mouse strains in two fractions (mitochondria and total cell) from five tissues: liver, quadriceps, heart, brain, and brown adipose (BA ...
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC2018Evolution of longevity improves immunity in Drosophila
Much has been learned about the genetics of aging from studies in model organisms, but still little is known about naturally occurring alleles that contribute to variation in longevity. For example, analysis of mutants and transgenes has identified insulin ...
JOHN WILEY & SONS LTD2018Thioester-containing proteins regulate the Toll pathway and play a role in Drosophila defence against microbial pathogens and parasitoid wasps
Bruno Lemaitre, Samuel Rommelaere, Anna Dostalova
Background: Members of the thioester-containing protein (TEP) family contribute to host defence in both insects and mammals. However, their role in the immune response of Drosophila is elusive. In this study, we address the role of TEPs in Drosophila immun ...
2017The Role of Lipid Competition for Endosymbiont-Mediated Protection against Parasitoid Wasps in Drosophila
Bruno Lemaitre, Fanny Schüpfer, Juan Camilo Paredes Escobar, Jeremy Keith Herren
Insects commonly harbor facultative bacterial endosymbionts, such as Wolbachia and Spiroplasma species, that are vertically transmitted from mothers to their offspring. These endosymbiontic bacteria increase their propagation by manipulating host reproduct ...
American Society for Microbiology2016Infection Dynamics and Immune Response in a Newly Described Drosophila-Trypanosomatid Association
Bruno Lemaitre, Anna Dostalova
Trypanosomatid parasites are significant causes of human disease and are ubiquitous in insects. Despite the importance of Drosophila melanogaster as a model of infection and immunity and a long awareness that trypanosomatid infection is common in the genus ...
American Society for Microbiology2015Genome Sequence of the Drosophila melanogaster Male-Killing Spiroplasma Strain MSRO Endosymbiont
Bruno Lemaitre, Ray Marcel Marin Florez, Juan Camilo Paredes Escobar, Jeremy Keith Herren
Spiroplasmas are helical and motile members of a cell wall-less eubacterial group called Mollicutes. Although all spiroplasmas are associated with arthropods, they exhibit great diversity with respect to both their modes of transmission and their effects o ...
American Society for Microbiology2015Transcriptomic profiling permits the identification of pollutant sources and effects in ambient water samples
Contaminant exposure is one possible contributor to population declines of endangered fish species in the Sacramento-San Joaquin Estuary, California, including the endangered delta smelt (Hypomesus transpacificus). Herein we investigated transcriptional re ...
Elsevier2014