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Dual proteomics of Drosophila melanogaster hemolymph infected with the heritable endosymbiont Spiroplasma poulsonii

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In naive individuals, the administration of bacterial lipopolysaccharide (LPS) provokes a rapid systemic increase in pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6, inducing an acute phase response inc ...

Elsevier2007

Insect immunity: the post-genomic era

Bruno Lemaitre

Insects have a complex and effective immune system, many components of which are conserved in mammals. But only in the last decade have the molecular mechanisms that regulate the insect immune response--and their relevance to general biology and human immu ...

Elsevier2006

The Toll immune-regulated Drosophila protein Fondue is involved in hemolymph clotting and puparium formation

Bruno Lemaitre

Clotting is critical in limiting hemolymph loss and initiating wound healing in insects as in vertebrates. It is also an important immune defense, quickly forming a secondary barrier to infection, immobilizing bacteria and thereby promoting their killing. ...

Elsevier2006

Cell-type-specific transcriptomics in chimeric models using transcriptome-based masks

Felix Naef

Regulatory networks involving different cell types control inflammation, morphogenesis and tissue homeostasis. Cell-type-specific transcriptional profiling offers a powerful tool for analyzing such cross-talk but is often hampered by mingling of cells with ...

2005

Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathway

Bruno Lemaitre

Innate immune recognition of microbes is a complex process that can be influenced by both the host and the microbe. Drosophila uses two distinct immune signaling pathways, the Toll and immune deficiency (Imd) pathways, to respond to different classes of mi ...

American Association of Immunologists2004

To identify new Drosophila genes involved in the immune response, we monitored the gene expression profile of adult flies in response to microbial infection by using high-density oligonucleotide microarrays encompassing nearly the full Drosophila genome. O ...

National Academy of Sciences2001

Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila

Bruno Lemaitre

In addition to its function in embryonic development, the NF-kappa B/rel-related gene dorsal (dl) of Drosophila is expressed in larval and adult fat body where its RNA expression is enhanced upon injury. Injury also leads to a rapid nuclear translocation o ...

Nature Publishing Group1995