Publications related to Design and modelling of a compliant constant-force surgical tool for objective assessment of ossicular chain mobility

First paleoproteome study of fossil fish otoliths and the pristine preservation of the biomineral crystal host

Anders Meibom, Jaroslaw Hubert Stolarski, Jinming Guo

Otoliths are calcium carbonate components of the stato-acoustical organ responsible for hearing and maintenance of the body balance in teleost fish. During their formation, control over, e.g., morphology and carbonate polymorph is influenced by complex ins ...

NATURE PORTFOLIO2023

Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

Bernard Schneider, Paola Andrea Solanes Vega

Viral delivery of exogenous coding sequences into the inner ear has the potential for therapeutic benefit for patients suffering genetic or acquired hearing loss. To devise improved strategies for viral delivery, we investigated two injection techniques, r ...

2020

Inner ear cellular imaging through scattering bone

Demetri Psaltis, Marilisa Romito

Inner ear imaging is important for the assessment of hearing disorders. A major cause of hearing loss is the damage to the sensory hair cells, which are located inside the cochlea, a spiral-shaped bone in the inner ear. Imaging of intracochear hair cells i ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Delivery of CRISPR/Cas9 using AAV-PHP.B in the inner ear leads to allele-specific inactivation of the mutated Tmc1 allele and protects auditory function in Beethoven mice

Bernard Schneider, Paola Andrea Solanes Vega, Sofia Carmen Suzanne Spataro

Hearing Loss (HL) is the most prevalent sensorineural disorder, affecting 360 million people worldwide. As genetic causes lead to 50% of pre-lingual deafness, gene therapy is considered as a potential therapeutic strategy. Mutations in the TMC1 gene are li ...

MARY ANN LIEBERT, INC2019

Imaging hair cells through laser-ablated cochlear bone

Demetri Psaltis, Ye Pu, Marilisa Romito

We report an innovative technique for the visualization of cells through an overlying scattering medium by combining femtosecond laser bone ablation and two-photon excitation fluorescence (TPEF) microscopy. We demonstrate the technique by imaging hair cell ...

OPTICAL SOC AMER2019

Bulged Eardrum Detection From 3D Data

Pascal Frossard, Ivana Tosic, Sofia Karygianni

Bulging is a medical characteristic of the eardrum that is crucial for the diagnosis of acute otitis media. This work proposes a novel classification method for distinguishing bulged eardrums from non-bulged ones. The method uses novel key features extract ...

IEEE2018

Automated Eardrum Registration From Light-Field Data

Pascal Frossard, Ivana Tosic, Sofia Karygianni

The performance of automated classification algorithms for medical images needs to be very high and especially robust in order to be adopted into healthcare. Most of the time the main challenge is unregistered data, since it is usually captured: 1) from di ...

IEEE2018

Optical proximity sensing system for atraumatic cochea implant surgery

Demetri Psaltis, Christophe Moser, Ye Pu

The design of a proximity sensor to be integrated into cochlea implants is described. The sensor allows the anticipation of contact between the cochlear implant and intracochlear structures, including the cochlear canal wall and basilar membrane, providing ...

2017

Surgical Anatomy of the Human Round Window Region: Implication for Cochlear Endoscopy Through the External Auditory Canal

Demetri Psaltis, Simon Nessim Henein

Objective: To enable development of an endoscope for cellular-level optical imaging of the inner ear. Study Design: A prospective study of 50 cadaveric human temporal bones to define detailed surgical anatomy of the round window (RW) region and the range o ...

Lippincott, Williams & Wilkins2016

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Design and modelling of a compliant constant-force surgical tool for objective assessment of ossicular chain mobility

First paleoproteome study of fossil fish otoliths and the pristine preservation of the biomineral crystal host

Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

Inner ear cellular imaging through scattering bone

Biomedical optical techniques for intracochlear cellular imaging

Delivery of CRISPR/Cas9 using AAV-PHP.B in the inner ear leads to allele-specific inactivation of the mutated Tmc1 allele and protects auditory function in Beethoven mice

Imaging hair cells through laser-ablated cochlear bone

Bulged Eardrum Detection From 3D Data

Automated Eardrum Registration From Light-Field Data

Optical proximity sensing system for atraumatic cochea implant surgery

Surgical Anatomy of the Human Round Window Region: Implication for Cochlear Endoscopy Through the External Auditory Canal

Graph Chatbot

Chat with Graph Search

Surgical Anatomy of the Human Round Window Region: Implication for Cochlear Endoscopy Through the External Auditory Canal

Optical proximity sensing system for atraumatic cochea implant surgery

Automated Eardrum Registration From Light-Field Data

Bulged Eardrum Detection From 3D Data

Delivery of CRISPR/Cas9 using AAV-PHP.B in the inner ear leads to allele-specific inactivation of the mutated Tmc1 allele and protects auditory function in Beethoven mice

Biomedical optical techniques for intracochlear cellular imaging

Inner ear cellular imaging through scattering bone

Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

Imaging hair cells through laser-ablated cochlear bone

First paleoproteome study of fossil fish otoliths and the pristine preservation of the biomineral crystal host