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Short Article Hypothalamic bile acid-TGR5 signaling protects from obesity

Related publications (38)

White adipose tissue distribution and amount are associated with increased white matter connectivity

Jean-Philippe Thiran, Gabriel Girard, Elda Fischi Gomez, Philipp Johannes Koch, Liana Okudzhava

Obesity represents a significant public health concern and is linked to various comorbidities and cognitive impairments. Previous research indicates that elevated body mass index (BMI) is associated with structural changes in white matter (WM). However, a ...

Hoboken2024

Unraveling behavior and cortical signals to guide the development of soft neuroprostheses for auditory restoration and spreading depolarization

Emilie Cornelia Maria Revol

Neuroprostheses have been used clinically for decades, to help restore or preserve brain functions, when pharmaceutical treatments are inefficient. Although great progress in the field has been made over the years to interface with the nervous system, surf ...

EPFL2024

Organ Neuroprosthetics: Connecting Transplanted and Artificial Organs with the Nervous System

Silvestro Micera

Implantable neural interfaces with the central and peripheral nervous systems are currently used to restore sensory, motor, and cognitive functions in disabled people with very promising results. They have also been used to modulate autonomic activities to ...

Wiley2024

Reconstruction of nerve functional topography using recruitment curves enables selective electrical stimulation

Silvestro Micera, Simone Romeni, Bianca Ziliotto

Multi-polar stimulation protocols have been used in the past to increase the selectivity of electrical stimulation of the nervous system. Nonetheless, the number of possible multipolar stimulation protocols is prohibitively large and cannot be explored dur ...

IEEE2023

Simultaneous decoding of cardiovascular and respiratory functional changes from pig intraneural vagus nerve signals

Silvestro Micera, Simone Romeni, Ivo Strauss

Objective. Bioelectronic medicine is opening new perspectives for the treatment of some major chronic diseases through the physical modulation of autonomic nervous system activity. Being the main peripheral route for electrical signals between central nerv ...

IOP PUBLISHING LTD2021

Bioelectronic medicine for the autonomic nervous system: clinical applications and perspectives

Silvestro Micera, Ivo Strauss

Bioelectronic medicine (BM) is an emerging new approach for developing novel neuromodulation therapies for pathologies that have been previously treated with pharmacological approaches. In this review, we will focus on the neuromodulation of autonomic nerv ...

IOP PUBLISHING LTD2021

Tutorial: a computational framework for the design and optimization of peripheral neural interfaces

Silvestro Micera, Simone Romeni, Giacomo Valle

Peripheral neural interfaces have been successfully used in the recent past to restore sensory-motor functions in disabled subjects and for the neuromodulation of the autonomic nervous system. The optimization of these neural interfaces is crucial for ethi ...

NATURE RESEARCH2020

High frequency shift in Carotid Sinus Nerve and Sympathetic Nerve activity in Type 2 Diabetic Rat Model

Silvestro Micera

Overactivity of the sympathetic nervous system (SNS) is associated to several cardiovascular and metabolic dysfunctions, such as hypertension and insulin resistance. Indirect biochemical measurements and surgical manipulations have provided preliminary evi ...

IEEE2019

Low vagal tone in two rat models of psychopathology involving high or low corticosterone stress responses

Maria del Carmen Sandi Perez, Jocelin Grosse, Damien Sébastien Huzard, Sriparna Ghosal

The two stress-responsive physiological systems, autonomic nervous system (ANS) and hypothalamus-pituitary-adrenal (HPA) axis exert complementary and interrelated actions in the organism. Individuals that suffer stress-related psychopathologies frequently ...

2019

Soft microfabricated neural implants: a path towards translational implementation

Nicolas Vachicouras

Neuroprosthetics are a class of medical devices that aim to restore lost or impaired functions of the nervous system by electrical stimulation or recording of neural tissue. State of the art neural implants suffer today from a mechanical mismatch compared ...

EPFL2019

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