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Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation

Related publications (34)

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Simulation based population synthesis

Michel Bierlaire, Gunnar Flötteröd, Bilal Farooq, Ricardo Daniel Hurtubia González

Microsimulation of urban systems evolution requires synthetic population as a key input. Currently, the focus is on treating synthesis as a fitting problem and thus various techniques have been developed, including Iterative Proportional Fitting (IPF) and ...

2013

Simulation based population synthesis

Michel Bierlaire, Gunnar Flötteröd, Bilal Farooq, Ricardo Daniel Hurtubia González

Pergamon-Elsevier Science Ltd2013

Predicting the occurrence and spatial extent of extreme avalanches is a longstanding issue. Using field data pooled from various sites within the same mountain range, authors showed that the avalanche size distribution can be described using either an extr ...

Springer-Verlag2012

A new approach to synthesize heterogeneous agents and their associations for urban microsimulations

Michel Bierlaire, Gunnar Flötteröd, Bilal Farooq

Microsimulation of urban transportation and land use evolution require base year, individual characteristics and disaggregate locations of the households and persons living in the study area. On the other hand, mainly due to privacy reasons, at best the ce ...

2012

Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase

Gadd45alpha is a nuclear protein encoded by a DNA damage-inducible gene. Through its interactions with other proteins, Gadd45alpha participates in the regulation of DNA repair, cell cycle, cell proliferation, and apoptosis. The NMR structure of human Gadd4 ...

American Society for Biochemistry and Molecular Biology2010

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The idea of stochastic sediment transport models emerged in the 1930s, notably with the doctoral work of Hans A. Einstein (1936). Einstein's seminal work gave impulse to several stochastic models, which usually led to thin-tailed or bounded distributions f ...

2010

Cyclin-dependent protein kinases (CDKs) are key regulators of the eukaryotic cell cycle and of the eukaryotic transcription machinery. Here, we report the characterisation of Pfcrk-3 (P. falciparum CDK-related kinase 3, PlasmoDB identifier PFD0740w), an un ...

American Society for Microbiology2010

Spatial isolation favours the divergence in microcystin net production by Microcystis in Ugandan freshwater lakes

Cyril Portmann, Karl Gademann

It is generally agreed that the hepatotoxic microcystins (MCs) are the most abundant toxins produced by cyanobacteria in freshwater. In various freshwater lakes in East Africa MC-producing Microcystis has been reported to dominate the phytoplankton, howeve ...

2010

Multi-experts scheduling system for real-time applications

Mario Bellino

This thesis focuses on the decisional process of autonomous systems, and more particularly, on the way to take a decision when the time at disposal in order to assess the whole situation is shorter than necessary. Indeed, numerous systems propose solutions ...

EPFL2009

An Oligomerized 53BP1 Tudor Domain Suffices for Recognition of DNA Double-Strand Breaks

Jürgen Brugger, Kristopher Pataky

53BP1, the vertebrate ortholog of the budding yeast Rad9 and fission yeast Crb2/Rhp9 checkpoint proteins, is recruited rapidly to sites of DNA double-strand breaks (DSBs). A tandem tudor domain in human 53BP1 that recognizes methylated residues in the hist ...

2009