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The effect of left ventricular contractility on arterial hemodynamics: A model-based investigation
Related publications (78)
Total arterial compliance estimated by a novel method and all-cause mortality in the elderly: the PROTEGER study
Nikolaos Stergiopoulos, Orestis Vardoulis
Aortic stiffness, assessed by carotid-to-femoral pulse wave velocity (PWV), often fails to predict cardiovascular (CV) risk and mortality in the very elderly. This may be due to the non-linear association between PWV and compliance or to blood pressure dec ...
Springer Verlag2014First in vivo application and evaluation of a novel method for non-invasive estimation of cardiac output
Nikolaos Stergiopoulos, Orestis Vardoulis
Surgical or critically ill patients often require continuous assessment of cardiac output (CO) for diagnostic purposes or for guiding therapeutic interventions. A new method of non-invasive CO estimation has been recently developed, which is based on press ...
Elsevier2014Effects of Isoflurane Anesthesia on Aortic Compliance and Systemic Hemodynamics in Compliant and Noncompliant Aortas
Objectives: To investigate the effect of general anesthesia on aortic compliance and other cardiovascular hemodynamics in chronically instrumented pigs with compliant and noncompliant (stiff) aortas. Design: Experimental study. Setting: University animal l ...
W B Saunders Co-Elsevier Inc2013Pulsatile blood flow in human bone assessed by laser-Doppler flowmetry and the interpretation of photoplethysmographic signals
Dimitri Nestor Alice Van De Ville, Jean-Noël Hyacinthe, Jonas Richiardi
Human bone blood flow, mean blood speed and the number of moving red blood cells were assessed (in arbitrary units), as a function of time, during one cardiac cycle. The measurements were obtained non-invasively on five volunteers by laser-Doppler flowmetr ...
Institute of Physics2013Opportunities for Targeting the Angiotensin-Converting Enzyme 2/Angiotensin-(1-7)/Mas Receptor Pathway in Hypertension
It is well known that the renin-angiotensin system (RAS) plays a pivotal role in the pathophysiology of cardiovascular diseases. This is well illustrated by the great success of ACE inhibitors and angiotensin (Ang) II AT(1) blockers in the treatment of hyp ...
Springer2013On the Estimation of Total Arterial Compliance from Aortic Pulse Wave Velocity
Nikolaos Stergiopoulos, Orestis Vardoulis
Total arterial compliance (C (T)) is a main determinant of cardiac afterload, left ventricular function and arterio-ventricular coupling. C (T) is physiologically more relevant than regional aortic stiffness. However, direct, in vivo, non-invasive, measure ...
Springer US2012The "systolic volume balance" method for the noninvasive estimation of cardiac output based on pressure wave analysis
Nikolaos Stergiopoulos, Orestis Vardoulis
Papaioannou TG, Vardoulis O, Stergiopulos N. The "systolic volume balance" method for the noninvasive estimation of cardiac output based on pressure wave analysis. Am J Physiol Heart Circ Physiol 302: H2064-H2073, 2012. First published March 16, 2012; doi: ...
2012Systolic Hypertension Mechanisms: Effect of Global and Local Proximal Aorta Stiffening on Pulse Pressure
Nikolaos Stergiopoulos, Philippe Reymond, Nico Westerhof
Decrease in arterial compliance leads to an increased pulse pressure, as explained by the Windkessel effect. Pressure waveform is the sum of a forward running and a backward running or reflected pressure wave. When the arterial system stiffens, as a result ...
Springer US2012Ambulatory arterial stiffness index does not accurately assess arterial stiffness
Nikolaos Stergiopoulos, Philippe Reymond, Patrick Segers
Introduction: The ambulatory arterial stiffness index (AASI), derived from ambulatory blood pressure monitoring (ABPM) recordings, has been proposed as a surrogate marker of arterial stiffness. However, there is controversy to what extent it reflects stiff ...
Lippincott, Williams & Wilkins2012Pressure and Flow Wave Propagation in Patient-Specific Models of the Arterial Tree
Blood flow in the arterial circulation induces hemodynamic forces that play an important role in various forms of vascular diseases. Temporal variation of the wall shear stress seems to play a significant role in atherogenesis and plaque stability. Flow in ...
EPFL2011