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Miniature neurotransmission is required to maintain Drosophila synaptic structures during ageing
Related publications (37)
Trio preserves motor synapses and prolongs motor ability during aging
Evelyne Ruchti, Brian Donal McCabe, Soumya Banerjee, Greta Limoni, Samuel William Vernon, Wei Jiao
The decline of motor ability is a hallmark feature of aging and is accompanied by degeneration of motor synaptic terminals. Consistent with this, Drosophila motor synapses undergo characteristic age -dependent structural fragmentation co -incident with dim ...
Cell Press2024Principles of Network Plasticity in Neocortical Microcircuits
Synaptic plasticity underlies our ability to learn and adapt to the constantly changing environment. The phenomenon of synapses changing their efficacy in an activity-dependent manner is often studied in small groups of neurons in vitro or indirectly throu ...
EPFL2023Digital reconstruction of the mammalian spinal cord: from anatomical reference volume to cell type atlas of the mouse spinal cord
The spinal cord is an elongated nervous structure that together with the brain forms the central nervous system. It relays sensory and motor information between the brain and the body, thus controlling most somatic and autonomic body functions. In recent y ...
EPFL2023Long-term plasticity induces sparse and specific synaptic changes in a biophysically detailed cortical model
Eilif Benjamin Muller, Michael Reimann, James Gonzalo King, Marwan Muhammad Ahmed Abdellah, Pramod Shivaji Kumbhar, András Ecker, Sirio Bolaños Puchet, James Bryden Isbister, Daniela Egas Santander, Jorge Blanco Alonso, Giuseppe Chindemi, Ioannis Magkanaris
Synaptic plasticity underlies the brain’s ability to learn and adapt. This process is often studied in small groups of neurons in vitro or indirectly through its effects on behavior in vivo. Due to the limitations of available experimental techniques, inve ...
2023A conditional glutamatergic synaptic vesicle marker for Drosophila
Evelyne Ruchti, Brian Donal McCabe
Glutamate is a principal neurotransmitter used extensively by the nervous systems of all vertebrate and invertebrate animals. It is primarily an excitatory neurotransmitter that has been implicated in nervous system development, as well as a myriad of brai ...
OXFORD UNIV PRESS INC2022Uncovering the neural encoding of behavior in the adult Drosophila motor system
One of the most important goals in neuroscience research has always been to understand how animals control their behavior. However, the long focus on the role of brain neurons in behavioral control might be missing the full story. In fact, brain-wide fluct ...
EPFL2022Neuromodulatory organization in the developing rat somatosensory cortex
Henry Markram, Srikanth Ramaswamy, Armando Romani, Cristina Colangelo, Alberto Antonietti, Joni Henrikki Herttuainen
The vast majority of cortical synapses are found in the neuropil which is implicated in multiple and diverse functions underlying brain computation. Unraveling the organizing principles of the cortical neuropil requires an intricate characterization of syn ...
2022Acquisition-dependent modulation of hippocampal neural cell adhesion molecules by associative motor learning
It is widely accepted that some types of learning involve structural and functional changes of hippocampal synapses. Cell adhesion molecules neural cell adhesion molecule (NCAM), its polysialylated form polysialic acid to NCAM (PSA-NCAM), and L1 are promin ...
FRONTIERS MEDIA SA2022Spinal V1 neurons inhibit motor targets locally and sensory targets distally
Rostro-caudal coordination of spinal motor output is essential for locomotion. Most spinal interneurons project axons longitudinally to govern locomotor output, yet their connectivity along this axis remains unclear. In this study, we use larval zebrafish ...
CELL PRESS2021Modeling spinal locomotor circuits for movements in developing zebrafish
Many spinal circuits dedicated to locomotor control have been identified in the developing zebrafish. How these circuits operate together to generate the various swimming movements during development remains to be clarified. In this study, we iteratively b ...
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