Publications related to New Vinylation and Alkynylation Strategies with Hypervalent Iodine Reagents and Diazo Compounds

New developments in iron-catalyzed carbon-carbon bond forming reactions

The goal of this thesis is to develop new carbon-carbon bond forming reactions using inexpensive and simple coupling partners like aryl halides (pseudohalides), sulfonyl derivatives, Grignard reagents, alkenes and alkynes with metal catalysis, preferably u ...

EPFL2009

Synthesis of novel pyrrolidine 3,4-diol derivatives as inhibitors of alpha-L-fucosidases

Pierre Vogel, Inmaculada Robina, Claudia Bello, Yolanda Vera-Ayoso

The stereoselective synthesis of new 3,4-dihydroxypyrrolidine derivatives starting from D-mannose, D-ribose and L-fucose is presented. Two synthetic strategies employing organometallic addition to hemiacetalic sugars followed by selective nucleophilic disp ...

2009

Cyclization and Cycloaddition Reactions of Cyclopropyl Carbonyls and Imines

Jérôme Waser, Filippo De Simone

Abstract: Activated cyclopropanes, such as vinyl and carbonyl cyclopropanes, are useful building blocks in organic chemistry due to their exceptional reactivity. This review focuses on the use of cyclopropyl carbonyls and imines in cyclization and cycloadd ...

2009

Chiral Bronsted Acid-Catalyzed Enantioselective Multicomponent Mannich Reaction: Synthesis of anti-1,3-Diamines Using Enecarbamates as Nucleophiles

Jieping Zhu

Reaction of aldehydes, anilines, and enecarbamates in dichloromethane in the presence of EtOH and a catalytic amt. of chiral phosphoric acid I afforded the Mannich adducts which were in situ reduced to anti-1,2-disubstituted 1,3-diamines II in excellent di ...

2009

B-Alkylcatecholborane-Mediated Tandem Radical Conjugated Addition-Aldol Cyclization

Philippe Renaud, Kurt Schenk

A one-pot procedure involving radical conjugate addition of B-alkylcatecholboranes to enones followed by intramolecular aldol reaction is reported. Application to the stereoselective synthesis of monocyclic and bicyclic products with up to four contiguous ...

2009

Nitrous Oxide Decomposition on the Binuclear $\left$ Center in Fe-ZSM-5 Zeolite

The reaction mechanism for nitrous oxide (

{N}_{2}O

) direct decomposition into molecular nitrogen and oxygen was studied on binuclear iron sites in Fe-ZSM-5 zeolite using the density functional theory (DFT). Starting from the hydroxylated bi-iron complex ...

2008

Use of sultines in the asymmetric synthesis of polypropionate antibiotics

Pierre Vogel, Maris Turks, Cotinica Craita, Freddy Fonquerne, Christopher Flowers, Laure Bouchez, Xiaogen Huang

At low temperature and in the presence of an acid catalyst, SO2 adds to 1,3-dienes equilibrating with the corresponding 3,6-dihydro-1,2-oxathiin-2-oxides (sultines). These compounds are unstable above -60 degrees C and equilibrate with the more stable 2,5- ...

De Gruyter2008

The Hydration of Chloroacetonitriles Catalyzed by Mono- and Dinuclear Ru-II- and Os-II-Arene Complexes

Christian Hartinger, Alexey Nazarov

The hydration of nitrites to the corresponding amides is all important reaction for both laboratory and industry purposes. The classical synthesis method requires harsh conditions, gives low yields, and is nonselective due to further hydrolysis of the amid ...

2008

Total synthesis of (-)-pseudolaric Acid B

Jérôme Waser

We report the enantioselective synthesis of pseudolaric acid B (1a), a diterpene acid isolated from the bark of Pseudolarix kaempferi Gordon, which displays interesting antifungal, antifertility, and cytotoxic activity against multidrug resistant cell line ...

2007

Myriad Planar Hexacoordinate Carbon Molecules Inviting Synthesis

Zhenhua Chen

The prototypal hexacoordinate C (phC) mol., CB62- (D6h), can be annulated by inserting arenes, olefins, or other one or two atom bridging groups into a perimeter B-B bond. Two single-atom units also can bridge opposite CB6 edges. These strategies allow the ...

2007

New Vinylation and Alkynylation Strategies with Hypervalent Iodine Reagents and Diazo Compounds

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New developments in iron-catalyzed carbon-carbon bond forming reactions

Synthesis of novel pyrrolidine 3,4-diol derivatives as inhibitors of alpha-L-fucosidases

Cyclization and Cycloaddition Reactions of Cyclopropyl Carbonyls and Imines

Chiral Bronsted Acid-Catalyzed Enantioselective Multicomponent Mannich Reaction: Synthesis of anti-1,3-Diamines Using Enecarbamates as Nucleophiles

B-Alkylcatecholborane-Mediated Tandem Radical Conjugated Addition-Aldol Cyclization

Nitrous Oxide Decomposition on the Binuclear $\left$ Center in Fe-ZSM-5 Zeolite

Use of sultines in the asymmetric synthesis of polypropionate antibiotics

The Hydration of Chloroacetonitriles Catalyzed by Mono- and Dinuclear Ru-II- and Os-II-Arene Complexes

Total synthesis of (-)-pseudolaric Acid B

Myriad Planar Hexacoordinate Carbon Molecules Inviting Synthesis

New developments in iron-catalyzed carbon-carbon bond forming reactions

Use of sultines in the asymmetric synthesis of polypropionate antibiotics

Synthesis of novel pyrrolidine 3,4-diol derivatives as inhibitors of alpha-L-fucosidases

The Hydration of Chloroacetonitriles Catalyzed by Mono- and Dinuclear Ru-II- and Os-II-Arene Complexes

Nitrous Oxide Decomposition on the Binuclear $\left$ Center in Fe-ZSM-5 Zeolite

Cyclization and Cycloaddition Reactions of Cyclopropyl Carbonyls and Imines

Myriad Planar Hexacoordinate Carbon Molecules Inviting Synthesis

Chiral Bronsted Acid-Catalyzed Enantioselective Multicomponent Mannich Reaction: Synthesis of anti-1,3-Diamines Using Enecarbamates as Nucleophiles

B-Alkylcatecholborane-Mediated Tandem Radical Conjugated Addition-Aldol Cyclization

Total synthesis of (-)-pseudolaric Acid B