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HP agents and biochemical interactions
Related publications (35)
Multi-sample/multi-nucleus parallel polarization and monitoring enabled by a fluid path technology compatible cryogenic probe for dissolution dynamic nuclear polarization
Andrea Capozzi, Jean-Noël Hyacinthe, Thanh Phong Kevin Lê
Low throughput is one of dissolution Dynamic Nuclear Polarization (dDNP) main shortcomings. Especially for clinical and preclinical applications, where direct 13C nuclei polarization is usually pursued, it takes hours to generate one single hyperpolarized ...
2023Variability and reproducibility of multi-echo T2 relaxometry: Insights from multi-site, multi-session and multi-subject MRI acquisitions
Jean-Philippe Thiran, Friedhelm Christoph Hummel, Tobias Kober, Tom Hilbert, Erick Jorge Canales Rodriguez, Gabriel Girard, Elda Fischi Gomez, Marco Pizzolato, Gian Franco Piredda, Thomas Yu, Takuya Morishita, Elena Beanato, Alessandro Daducci, Maximilian Jonas Wessel, Chang-Hyun Park, Philipp Johannes Koch, Andéol Geoffroy Cadic-Melchior, Julia Brügger
Quantitative magnetic resonance imaging (qMRI) can increase the specificity and sensitivity of conventional weighted MRI to underlying pathology by comparing meaningful physical or chemical parameters, measured in physical units, with normative values acqu ...
2022Metabolic contrast agents produced from transported solid C-13-glucose hyperpolarized via dynamic nuclear polarization
Andrea Capozzi, Arthur César Pinon
Magnetic Resonance Imaging combined with hyperpolarized C-13-labelled metabolic contrast agents produced via dissolution Dynamic Nuclear Polarization can, non-invasively and in real-time, report on tissue specific aberrant metabolism. However, hyperpolariz ...
NATURE RESEARCH2021Methods to Enhance Nuclear Magnetic Resonance Sensitivity at High Magnetic Field
MR is a well-established technique routinely used in preclinical and clinical studies. This thesis focussed on the improvement of sensitivity of different methods in MR.
Hyperpolarized 129Xe gas is used for studying pulmonary disease or cerebral perfusion ...
EPFL2021Mechanistic studies of DNP and applications of hyperpolarized probes to study renal physiology and metabolism
Dissolution dynamic nuclear polarization (dDNP) is a powerful technique that enhances the magnetic resonance signal of nuclear spins by several orders of magnitude. DNP relies on the principle of cross-relaxation by electron spins driven out of equilibrium ...
EPFL2021Late post‐natal neurometabolic development in healthy male rats using 1 H and 31 P Magnetic Resonance Spectroscopy
Rolf Gruetter, Cristina Ramona Cudalbu, Dunja Simicic, Veronika Rackayová, Guillaume Donati
Brain metabolism evolves rapidly during early post‐natal development in the rat. While changes in amino acids, energy metabolites, antioxidants or metabolites involved in phospholipid metabolism have been reported in the early stages, neurometabolic change ...
2021Nanodiamond Relaxometry-Based Detection of Free-Radical Species When Produced in Chemical Reactions in Biologically Relevant Conditions
Diamond magnetometry is a quantum sensing method involving detection of magnetic resonances with nanoscale resolution. For instance, T1 relaxation measurements, inspired by equivalent concepts in magnetic resonance imaging (MRI), provide a signal that is e ...
AMER CHEMICAL SOC2020An Overview of Functional Magnetic Resonance Imaging Techniques for Organizational Research
Kerstin Preuschoff, Leyla Loued-Khenissi
Functional magnetic resonance imaging is a galvanizing tool for behavioral scientists. It provides a means by which to see what the brain does while a person thinks, acts, or perceives, without invasive procedures. In this, fMRI affords us a relatively eas ...
SAGE PUBLICATIONS INC2019Development and Optimization of Methods for Accelerated Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) has yielded great success as a medical imaging modality in the past decades, and its excellent soft tissue contrast is used in clinical routine to support diagnosis today. However, MRI is still facing challenges. For exampl ...
EPFL2018Methods to hyperpolarize nuclear spins via dissolution and sublimation DNP at high magnetic field
Dynamic Nuclear Polarization (DNP) is, nowadays, the most well-established and widespread Nuclear Magnetic Resonance (NMR) hyperpolarization technique. With respect to other methods, the main advantage of DNP is, with no doubt, its versatility. In theory e ...
EPFL2016