Cell (biology)The cell is the basic structural and functional unit of all forms of life. Every cell consists of cytoplasm enclosed within a membrane, and contains many macromolecules such as proteins, DNA and RNA, as well as many small molecules of nutrients and metabolites. The term comes from the Latin word cellula meaning 'small room'. Cells can acquire specified function and carry out various tasks within the cell such as replication, DNA repair, protein synthesis, and motility. Cells are capable of specialization and mobility within the cell.
Living systemsLiving systems are open self-organizing life forms that interact with their environment. These systems are maintained by flows of information, energy and matter. In the last few decades, some scientists have proposed that a general living systems theory is required to explain the nature of life. Such a general theory, arising out of the ecological and biological sciences, attempts to map general principles for how all living systems work.
Mad2Mad2 (mitotic arrest deficient 2) is an essential spindle checkpoint protein. The spindle checkpoint system is a regulatory system that restrains progression through the metaphase-to-anaphase transition. The Mad2 gene was first identified in the yeast S. cerevisiae in a screen for genes which when mutated would confer sensitivity to microtubule poisons. The human orthologues of Mad2 (MAD2L1 and MAD2L2) were first cloned in a search for human cDNAs that would rescue the microtubule poison-sensitivity of a yeast strain in which a kinetochore binding protein was missing.
BuddingBudding or blastogenesis is a type of asexual reproduction in which a new organism develops from an outgrowth or bud due to cell division at one particular site. For example, the small bulb-like projection coming out from the yeast cell is known as a bud. Since the reproduction is asexual, the newly created organism is a clone and excepting mutations is genetically identical to the parent organism. Organisms such as hydra use regenerative cells for reproduction in the process of budding.
Financial risk modelingFinancial risk modeling is the use of formal mathematical and econometric techniques to measure, monitor and control the market risk, credit risk, and operational risk on a firm's balance sheet, on a bank's trading book, or re a fund manager's portfolio value; see Financial risk management. Risk modeling is one of many subtasks within the broader area of financial modeling. Risk modeling uses a variety of techniques including market risk, value at risk (VaR), historical simulation (HS), or extreme value theory (EVT) in order to analyze a portfolio and make forecasts of the likely losses that would be incurred for a variety of risks.
Continental divideA continental divide is a drainage divide on a continent such that the drainage basin on one side of the divide feeds into one ocean or sea, and the basin on the other side either feeds into a different ocean or sea, or else is endorheic, not connected to the open sea. Every continent on earth except Antarctica (which has no known significant, definable free-flowing surface rivers) has at least one continental drainage divide; islands, even small ones like Killiniq Island on the Labrador Sea in Canada, may also host part of a continental divide or have their own island-spanning divide.
Continental Divide of the AmericasThe Continental Divide of the Americas (also known as the Great Divide, the Western Divide or simply the Continental Divide; Divisoria continental de América, Gran Divisoria) is the principal, and largely mountainous, hydrological divide of the Americas. The Continental Divide extends from the Bering Strait to the Strait of Magellan, and separates the watersheds that drain into the Pacific Ocean from those river systems that drain into the Atlantic and Arctic Ocean, including those that drain into the Gulf of Mexico, the Caribbean Sea, and Hudson Bay.
