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Method and light microscope with a plurality of arrays of photon-counting detector elements

Related publications (35)

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Electrochemical Imaging of Cells and Tissues

Hubert Girault, Andreas Stephan Lesch, Tzu-En Lin

The technological and experimental progress in electrochemical imaging of biological specimens is discussed with a view on potential applications for skin cancer diagnostics, reproductive medicine and microbial testing. The electrochemical analysis of sing ...

2018

Sampling the Multiple Facets of Light

Gilles Baechler

The theme of this thesis revolves around three important manifestations of light, namely its corpuscular, wave and electromagnetic nature. Our goal is to exploit these principles to analyze, design and build imaging modalities by developing new signal proc ...

EPFL2018

Dynamic range extension for photon counting arrays

Edoardo Charbon, Claudio Bruschini, Ivan Michel Antolovic

Confocal microscopes use photomultiplier tubes and hybrid detectors due to their large dynamic range, which typically exceeds the one of single-photon avalanche diodes (SPADs). The latter, due to their photon counting operation, are usually limited to an o ...

2018

Block Face Scanning Electron Microscopy of Fluorescently Labeled Axons Without Using Near Infra-Red Branding

Graham Knott, Catherine Maclachlan

In this article, we describe the method that allows fluorescently tagged structures such as axons to be targeted for electron microscopy (EM) analysis without the need to convert their labels into electron dense stains, introduce any fiducial marks, or ima ...

2018

CORRELATED MULTIPLE SAMPLING CMOS IMAGE SENSOR

Assim Boukhayma

A CMOS image sensor including at least one pixel and one circuit arranged to receive, on a first node of the circuit, an analog signal representative of the luminosity level received by the pixel, the circuit being capable of successively acquiring 2n samp ...

2016

Nanoscopy in nonlinear scanning fluorescence imaging systems

Grégoire Pierre Jean Laporte

In the last 30 years, superresolution in optical microscopy has been a major field of research. During this time, different techniques have been created to break the diffraction limit in order to make observations at a nanometric scale. Given that optical ...

EPFL2016

Compressed imaging by sparse random convolution

Theo Lasser, Aurélien Bourquard, Antonio Lopez

The theory of compressed sensing (CS) shows that signals can be acquired at sub-Nyquist rates if they are sufficiently sparse or compressible. Since many images bear this property, several acquisition models have been proposed for optical CS. An interestin ...

Optical Society of America2016

Intensity-Based Point-Spread-Function-Aware Registration for Multi-View Applications in Optical Microscopy

Michael Stefan Daniel Liebling

We present an algorithm to spatially register two volumetric datasets related via a rigid-body transform and degraded by an anisotropic point-spread-function (PSF). Registration is necessary, for example, when fusing data in multi-view microscopy. Automati ...

2015

Optical microscopy for biology and life sciences

Theo Lasser, Marcel Leutenegger

Optical microscopy has become a major non- or minimally invasive tool for investigating living organisms such as cells, tissues or small animals. Being such an essential tool for research and because lacking knowledge and insight in the working principles ...

Laboratoire d'Optique Biomédicale, EPFL2014

Portable advanced off-axis camera for quantitative phase microscopy

Christian Depeursinge

We propose and experimentally demonstrate a device in which common-path interferometry combined with off-axis holographic geometry is used to realize a digital holographic camera which can be attached to the camera port of a conventional transmission micro ...

Spie-Int Soc Optical Engineering2014