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Human circadian rhythms and urban density: celebrating the natural day-night cycle

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Circadian cycles and cell cycles are two fundamental periodic processes with a period in the range of 1 day. Consequently, coupling between such cycles can lead to synchronization. Here, we estimated the mutual interactions between the two oscillators by t ...

Nature / European Molecular Biology Organization2014

Modelling 'non-visual' effects of daylighting in a residential environment

Marilyne Andersen, Sharon Jane Gochenour, Steven W. Lockley

The importance of light not only as a therapeutic tool but as an essential element of healthy living has been highlighted by the recent discovery of a specialized photoreceptor in the eye responsible for synchronizing our internal circadian pacemaker. This ...

Elsevier2013

Circadian rhythms in insect disease vectors

Antonio Carlos Alves Meireles Filho

Organisms from bacteria to humans have evolved under predictable daily environmental cycles owing to the Earth's rotation. This strong selection pressure has generated endogenous circadian clocks that regulate many aspects of behaviour, physiology and meta ...

Fundaco Oswaldo Cruz2013

A framework for predicting the non-visual effects of daylight – Part I: photobiology-based model

Marilyne Andersen, Steven W. Lockley

This paper investigates the formulation of a modelling framework for the nonvisual effects of daylight, such as entrainment of the circadian system and maintenance of alertness. The body of empirical data from photobiology studies is now sufficient to star ...

SAGE Publications2012

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

Johan Auwerx, Xuan Zhao

The circadian clock acts at the genomic level to coordinate internal behavioural and physiological rhythms via the CLOCK-BMAL1 transcriptional heterodimer. Although the nuclear receptors REV-ERB-α and REV-ERB-β have been proposed to form an accessory feedb ...

2012

Circadian and Wake-Dependent Effects on the Pupil Light Reflex in Response to Narrow-Bandwidth Light Pulses

Lorette Leon

PURPOSE. Nonvisual light-dependent functions in humans are conveyed mainly by intrinsically photosensitive retinal ganglion cells, which express melanopsin as photopigment. We aimed to identify the effects of circadian phase and sleepiness across 24 hours ...

Association for Research in Vision and Ophthalmology2012

Lighting and human needs in built spaces

Marilyne Andersen

This presentation will discuss how recent findings in photobiology about the correlation between lighting and the human circadian system can prospectively be applied to architectural design, with a focus on healthcare and housing environments. Outcomes of ...

2012

Sex difference in the near-24-hour intrinsic period of the human circadian timing system

Mirjam Münch

The circadian rhythms of melatonin and body temperature are set to an earlier hour in women than in men, even when the women and men maintain nearly identical and consistent bedtimes and wake times. Moreover, women tend to wake up earlier than men and exhi ...

2011

Genome-Wide and Phase-Specific DNA-Binding Rhythms of BMAL1 Control Circadian Output Functions in Mouse Liver

Felix Naef, Jacques Rougemont, Guillaume Rey

The mammalian circadian clock uses interlocked negative feedback loops in which the heterodimeric basic helix-loop-helix transcription factor BMAL1/CLOCK is a master regulator. While there is prominent control of liver functions by the circadian clock, the ...

2011

Quantitative Analysis of Robustness in Systems Biology

Marc Hafner

To characterize the behavior and robustness of cellular circuits is a major challenge for Systems Biology. Many of the published methods that address this question quantify the local robustness of the models. In this thesis, I tried to underpin the inappro ...

EPFL2010