Publications related to Cognitive Impairment and Metabolite Profile Alterations in the Hippocampus and Cortex of Male and Female Mice Exposed to a Fat and Sugar-Rich Diet are Normalized by Diet Reversal

Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus

Rolf Gruetter, João Miguel das Neves Duarte

Diabetes affects the morphology and plasticity of the hippocampus, and leads to learning and memory deficits. Caffeine has been proposed to prevent memory impairment upon multiple chronic disorders with neurological involvement. We tested whether long-term ...

2019

Constitutive differences in glucocorticoid responsiveness are related to divergent spatial information processing abilities

Maria del Carmen Sandi Perez, Simone Astori, Eleni Vasilaki, Damien Sébastien Huzard

The stress response facilitates survival through adaptation and is intimately related to cognitive processes. The Morris water maze task probes spatial learning and memory in rodents and glucocorticoids (i.e. corticosterone (CORT) in rats) have been sugges ...

2019

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

Johan Auwerx, Dina Hofer

N-acetylaspartate (NAA) is synthesized by aspartate N-acetyltransferase (gene: Nat8l) from acetyl-coenzyme A and aspartate. In the brain, NAA is considered an important energy metabolite for lipid synthesis. However, the role of NAA in peripheral tissues r ...

FEDERATION AMER SOC EXP BIOL2019

Glycogen metabolism is impaired in the brain of male type 2 diabetic Goto‐Kakizaki rats

João Miguel das Neves Duarte, Ana Francisca Leal Silva Soares

Diabetes impacts the central nervous system predisposing to cognitive decline. While glucose is the main source of energy fueling the adult brain, brain glycogen is necessary for adequate neuronal function, synaptic plasticity and memory. In this study, we ...

2019

High-fat diet consumption alters energy metabolism in the mouse hypothalamus

Rolf Gruetter, João Miguel das Neves Duarte, Antoine Timothée Cherix, Blanca Lizarbe Serra, Jean-René Cardinaux

BACKGROUND/OBJECTIVES: High-fat diet consumption is known to trigger an inflammatory response in the hypothalamus, which has been characterized by an initial expression of pro-inflammatory genes followed by hypothalamic astrocytosis, microgliosis, and the ...

2019

Giant shape memory and domain memory effects in antiferroelectric single crystals

Dragan Damjanovic, Fangping Zhuo, Yaming Zhou, Yiling Zhang

We report irreversible and reversible antiferroelectric-ferroelectric phase transitions, shape memory and domain memory effects in (Pb,La)(Zr,Sn,Ti)O3 antiferroelectric tetragonal single crystals. We find that electric-field-induced antiferroelectric to fe ...

2019

Non-invasive diagnosis and metabolic consequences of congenital portosystemic shunts in C57BL/6 J mice

Hongxia Lei, Ana Francisca Leal Silva Soares

This study demonstrates the suitability of magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) for the imaging of congenital portosystemic shunts (PSS) in mice, a vascular abnormality in which mesenteric blood bypasses the liver and i ...

2018

Sexual dimorphism in hepatic lipids is associated with the evolution of metabolic status in mice

Rolf Gruetter, Hongxia Lei, Jonathan Paz Montoya, Marc Moniatte, Ana Francisca Leal Silva Soares

Ectopic lipid accumulation in the liver is implicated in metabolic disease in an age- and sex-dependent manner. The role of hepatic lipids has been well established within the scope of metabolic insults in mice, but has been insufficiently characterized un ...

Wiley-Blackwell2017

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Cognitive Impairment and Metabolite Profile Alterations in the Hippocampus and Cortex of Male and Female Mice Exposed to a Fat and Sugar-Rich Diet are Normalized by Diet Reversal

Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus

Constitutive differences in glucocorticoid responsiveness are related to divergent spatial information processing abilities

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

Long-term verbal memory deficit and associated hippocampal alterations in 22q11.2 deletion syndrome

Glycogen metabolism is impaired in the brain of male type 2 diabetic Goto‐Kakizaki rats

High-fat diet consumption alters energy metabolism in the mouse hypothalamus

Giant shape memory and domain memory effects in antiferroelectric single crystals

Non-invasive diagnosis and metabolic consequences of congenital portosystemic shunts in C57BL/6 J mice

Study of cortical energy metabolism during sensory stimulation-induced brain activity by ¹³C magnetic resonance spectroscopy in vivo

Sexual dimorphism in hepatic lipids is associated with the evolution of metabolic status in mice

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Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus

Constitutive differences in glucocorticoid responsiveness are related to divergent spatial information processing abilities

Long-term verbal memory deficit and associated hippocampal alterations in 22q11.2 deletion syndrome

Glycogen metabolism is impaired in the brain of male type 2 diabetic Goto‐Kakizaki rats

Sexual dimorphism in hepatic lipids is associated with the evolution of metabolic status in mice

Non-invasive diagnosis and metabolic consequences of congenital portosystemic shunts in C57BL/6 J mice

High-fat diet consumption alters energy metabolism in the mouse hypothalamus

Giant shape memory and domain memory effects in antiferroelectric single crystals

Study of cortical energy metabolism during sensory stimulation-induced brain activity by ¹³C magnetic resonance spectroscopy in vivo

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health