Protein microarrayA protein microarray (or protein chip) is a high-throughput method used to track the interactions and activities of proteins, and to determine their function, and determining function on a large scale. Its main advantage lies in the fact that large numbers of proteins can be tracked in parallel. The chip consists of a support surface such as a glass slide, nitrocellulose membrane, bead, or microtitre plate, to which an array of capture proteins is bound. Probe molecules, typically labeled with a fluorescent dye, are added to the array.
Adaptive immune systemThe adaptive immune system, also known as the acquired immune system, or specific immune system is a subsystem of the immune system that is composed of specialized, systemic cells and processes that eliminate pathogens or prevent their growth. The acquired immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Like the innate system, the adaptive immune system includes both humoral immunity components and cell-mediated immunity components and destroys invading pathogens.
InfinitesimalIn mathematics, an infinitesimal number is a quantity that is closer to zero than any standard real number, but that is not zero. The word infinitesimal comes from a 17th-century Modern Latin coinage infinitesimus, which originally referred to the "infinity-th" item in a sequence. Infinitesimals do not exist in the standard real number system, but they do exist in other number systems, such as the surreal number system and the hyperreal number system, which can be thought of as the real numbers augmented with both infinitesimal and infinite quantities; the augmentations are the reciprocals of one another.
Smooth infinitesimal analysisSmooth infinitesimal analysis is a modern reformulation of the calculus in terms of infinitesimals. Based on the ideas of F. W. Lawvere and employing the methods of , it views all functions as being continuous and incapable of being expressed in terms of discrete entities. As a theory, it is a subset of synthetic differential geometry. The nilsquare or nilpotent infinitesimals are numbers ε where ε2 = 0 is true, but ε = 0 need not be true at the same time.
Transcription activator-like effector nucleaseTranscription activator-like effector nucleases (TALEN) are restriction enzymes that can be engineered to cut specific sequences of DNA. They are made by fusing a TAL effector DNA-binding domain to a DNA cleavage domain (a nuclease which cuts DNA strands). Transcription activator-like effectors (TALEs) can be engineered to bind to practically any desired DNA sequence, so when combined with a nuclease, DNA can be cut at specific locations.
Rosetta (bioinformatics)Rosetta is a software package for protein structure prediction. Originally introduced by the Baker laboratory at the University of Washington in 1998 as an ab initio approach to structure prediction, Rosetta has since branched into several development streams and distinct services, providing features such as macromolecular docking and protein design. Many of the graduate students and other researchers involved in Rosetta's initial development have since moved to other universities and research institutions, and subsequently enhanced different parts of the Rosetta project.
Hyperreal numberIn mathematics, the system of hyperreal numbers is a way of treating infinite and infinitesimal (infinitely small but non-zero) quantities. The hyperreals, or nonstandard reals, *R, are an extension of the real numbers R that contains numbers greater than anything of the form (for any finite number of terms). Such numbers are infinite, and their reciprocals are infinitesimals. The term "hyper-real" was introduced by Edwin Hewitt in 1948. The hyperreal numbers satisfy the transfer principle, a rigorous version of Leibniz's heuristic law of continuity.
