Publication
Premature Vertebral Mineralization in hmx1-Mutant Zebrafish
Related publications (39)
Notch1 signaling is limited in healthy mature kidneys in vivo
ObjectiveA Delta-Notch signaling component, Notch1, is involved in the normal development and multiple disorders of the kidney. Although the increase in Notch1 signaling is crucial to these pathogeneses, the basal signaling level in 'healthy' mature kidney ...
SPRINGERNATURE2023Differential impact of TGF beta/SMAD signaling activity elicited by Activin A and Nodal on endoderm differentiation of epiblast stem cells
Allocation of cells to an endodermal fate in the gastrulating embryo is driven by Nodal signaling and consequent activation of TGF beta pathway. In vitro methodologies striving to recapitulate the process of endoderm differentiation, however, use TGF beta ...
WILEY2022Genetic dissection of the role of BMP signaling for the development of the auditory brainstem nuclei and the large calyx of Held synapse
Synapses are key elements for communication within the complex network of neurons that make up our brain. Interestingly, synaptic connections can differ greatly in form and function, depending on the specific circuit into which they are embedded. In this P ...
EPFL2016Wnt Ligands Secreted by Subepithelial Mesenchymal Cells Are Essential for the Survival of Intestinal Stem Cells and Gut Homeostasis
Michel Aguet, Andreas Eduard Moor
Targeting of Wnt signaling represents a promising anti-cancer therapy. However, the consequences of systemically attenuating the Wnt pathway in an adult organism are unknown. Here, we globally prevent Wnt secretion by genetically ablating Wntless. We find ...
Elsevier2016ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm
The secreted glycoprotein sonic hedgehog (Shh) is expressed in the prechordal mesoderm, where it plays a crucial role in induction and patterning of the ventral forebrain. Currently little is known about how Shh is regulated in prechordal tissue. Here we s ...
Company of Biologists2015Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis
Olivier Martin, Gerardo Turcatti, Nicolas Jean Philippe Guex, Marc Chambon
The Wnt pathway, which controls crucial steps of the development and differentiation programs, has been proposed to influence lipid storage and homeostasis. In this paper, using an unbiased strategy based on high-content genome-wide RNAi screens that monit ...
Nature Publishing Group2015Wnt-regulated dynamics of positional information in zebrafish somitogenesis
How signaling gradients supply positional information in a field of moving cells is an unsolved question in patterning and morphogenesis. Here, we ask how a Wnt signaling gradient regulates the dynamics of a wavefront of cellular change in a flow of cells ...
2014BMP signaling specifies the development of a large and fast CNS synapse
Graham Knott, Ralf Schneggenburger, Enida Gjoni, Elin Kristina Kronander, Le Xiao
excitatory synapses with multiple active zones ensure reliable and fast information transfer at specific points in neuronal circuits. However, the mechanisms that determine synapse size in CNS circuits are largely unknown. Here we use the calyx of Held syn ...
Nature Publishing Group2013The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription
Pygopus has been discovered as a fundamental Wnt signaling component in Drosophila. The mouse genome encodes two Pygopus homologs, Pygo1 and Pygo2. They serve as context-dependent beta-catenin coactivators, with Pygo2 playing the more important role. All P ...
Company Of Biologists Ltd2013Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice
Extracellular signals in development, physiology, homeostasis and disease often act by regulating transcription. Herein we describe a general method and specific resources for determining where and when such signaling occurs in live animals and for systema ...
Company Of Biologists Ltd2012