Publication
Real-time monitoring of single-cell secretion with a high-throughput nanoplasmonic microarray
Related publications (35)
Investigating the effect of inflammation on the progression of B-cell lymphoma dissemination in the sentinel lymph node
Lymphomas are a group of heterogeneous blood cancers that arise from lymphocytes. The two primary clinical classifications of lymphomas are Hodgkin's lymphoma (HL), and non-Hodgkin's lymphoma (NHL). In particular, B-cell lymphoma refers to the malignancies ...
EPFL2023KRAB zinc finger proteins link heterochromatin maintenance to replicative stress and inflammation in diffuse large B-cell lymphoma
Filipe Amândio Brandão Sanches Vong Martins
Genomic instability enhances cancer progression by favoring clonal diversity, yet uncontrolled replicative stress can lead to mitotic catastrophe and inflammatory responses promoting immune rejection. KRAB-containing zinc finger proteins (KZFPs) are epigen ...
EPFL2023Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma
Bruno Emanuel Ferreira De Sousa Correia, George Coukos, Elisa Oricchio, Jessica Sordet, Natalya Katanayeva, Julien Racle, Sarah Wehrle, Elena Battistello, Stephanie Jocelyne Sungalee, Elie Charles Eugène Dheilly, Giovanni Ciriello, Marco Mina
Genomic alterations in cancer cells can influence the immune system to favor tumor growth. In non-Hodgkin lymphoma, physiological interactions between B cells and the germinal center microenvironment are coopted to sustain cancer cell proliferation. We fou ...
2020Label-free plasmonic biosensors for real-time live cell analysis
For decades, the understanding of life has been focused on its most fundamental building blocks: molecules. Deciphering the dynamic activities of protein molecules in human cells is of vital significance for fundamental and clinical studies. The minuscule ...
EPFL2019Novel therapeutic strategies targeting the B-cell receptor signaling and antigen presentation pathways in non-Hodgkin lymphoma
B-cell non-Hodgkin lymphomas (B-NHLs) are a heterogeneous group of tumors deriving from the malignant transformation of B cells. The two most common B-NHL subtypes are follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL), which account togeth ...
EPFL2019An integrated nanoplasmonic biosensor for monitoring cytokine secretion from single cells
Hatice Altug, George Coukos, Xiaokang Li, Filiz Yesilköy, Alexander Belushkin, Maria Soler Aznar
An innovative nanoplasmonic biosensor was presented for real-time label-free monitoring of cytokine secretion at single-cell resolution. This biosensor is integrated with a uniquely designed microfluidic device that provides a microchamber for cell incubat ...
IEEE2019Lymphoma Chemotherapy: Hungry Macrophages Strike the Final Blow
Macrophages modulate tumor response to chemotherapy; in this issue, Lossos and colleagues show that high-dose alkylating agents instigate a synthetic lethal program in lymphoma cells that is independent of DNA damage and involves recruitment and priming of ...
AMER ASSOC CANCER RESEARCH2019Histone Modifications in Development and Malignancy
Non-Hodgkin lymphoma (NHL) development is driven by the accumulations of multiple genetic, epigenetic, and chromosomal alterations. These lesions can lead to modifications of the chromatin architecture. To identify novel oncogenic interactions driven by mo ...
AMER SOC HEMATOLOGY2019Optofluidic nanoplasmonic biosensor for label-free live cell analysis in real time
Hatice Altug, Xiaokang Li, Filiz Yesilköy, Alexander Belushkin, Maria Soler Aznar
Cell signaling activities play a critical role in physiological and disease processes. The analysis of the tumor microenvironment or the immune system activation is nowadays providing valuable insights towards disease understanding and novel therapies deve ...
2018Functional characterization of the virulence determinant ESX-1 from Mycobacterium tuberculosis
Tuberculosis (TB) is a chronic infectious disease that mainly affects the lungs and causes extensive human morbidity and mortality. It results from infection with Mycobacterium tuberculosis, a slow-growing intracellular pathogen that can replicate and surv ...
EPFL2018