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Coral holobiont cues prime Endozoicomonas for a symbiotic lifestyle

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Inflammasome Activation and Function During Infection with Mycobacterium tuberculosis

Andrea Ablasser

Tuberculosis (TB) is caused by infection with Mycobacterium tuberculosis (Mtb) and represents one of the most relevant bacterial diseases worldwide. Recent advances have yielded new insights into the molecular basis of the immune response required for rest ...

Springer Int Publishing Ag2016

Photosymbiosis and the expansion of shallow-water corals

Anders Meibom, Jaroslaw Hubert Stolarski

Roughly 240 million years ago (Ma), scleractinian corals rapidly expanded and diversified across shallow marine environments. The main driver behind this evolution is uncertain, but the ecological success of modern reefbuilding corals is attributed to thei ...

Amer Assoc Advancement Science2016

The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors

Bruno Lemaitre, Fanny Schüpfer

The innate immune system needs to distinguish between harmful and innocuous stimuli to adapt its activation to the level of threat. How Drosophila mounts differential immune responses to dead and live Gram-negative bacteria using the single peptidoglycan r ...

Nature Publishing Group2016

The role of cGAS in innate immunity and beyond

Andrea Ablasser, Muhammet Fatih Gülen

The sensing of foreign DNA is crucial for host defense against several pathogens. In the cytosol the enzyme cyclic GMP-AMP synthase (cGAS) is critical for the recognition of pathogen-derived DNA and provides key signals that initiate immune responses. Beyo ...

2016

In vitro micro-physiological models for translational immunology

Martinus Gijs

The immune system is a source of regulation of the human body and is key for its stable functioning. Animal models have been successfully used for many years to study human immunity and diseases and provided significant contributions to the development of ...

Royal Society of Chemistry2015

Global change has caused a worldwide increase in reports of Vibrio-associated diseases with ecosystem-wide impacts on humans and marine animals. In Europe, higher prevalence of human infections followed regional climatic trends with outbreaks occurring dur ...

Frontiers Research Foundation2015

Coral bleaching poses a threat to coral reefs worldwide. As a consequence of the temperature-induced breakdown in coral–dinoflagellate symbiosis, bleaching can have extensive effects on reef communities. However, our understanding of bleaching at a cellula ...

Springer Verlag2014

Methods to study Drosophila immunity

Bruno Lemaitre, Olivier Binggeli, Andrew Jonathan Bretscher

Innate immune mechanisms are well conserved throughout evolution, and many theoretical concepts, molecular pathways and gene networks are applicable to invertebrate model organisms as much as vertebrate ones. Drosophila immunity research benefits from an e ...

Elsevier2014

The contribution of the host stress response to the pathogenesis of Pseudomonas entomophila in the Drosophila intestine

Sveta Chakrabarti

Recently, several studies done in Drosophila have revealed that efficient and rapid recovery from bacterial infection in the gut is possible only when bacterial clearance by the immune system is coordinated with repair through renewal of the epithelium dam ...

EPFL2013

New generation vaccines, which are subunit vaccines, have considerably improved safety profiles, but are often poorly immunogenic, especially when administered through mucosal routes. Also, the diversity of the mechanisms of action of infectious pathogens ...

EPFL2012