Publication
Genetic selection for low glucocorticoid responsiveness recapitulates PTSD-related phenotypes: a behavioral, neuroimaging and sleep-physiology study
Related publications (77)
Adolescent Stress-Induced Ventral Hippocampus Redox Dysregulation Underlies Behavioral Deficits and Excitatory/Inhibitory Imbalance Related to Schizophrenia
Maria del Carmen Sandi Perez, Dogukan Hazar Ülgen, Thamyris Silva
Background and hypothesis: Redox dysregulation has been proposed as a convergent point of childhood trauma and the emergence of psychiatric disorders, such as schizophrenia (SCZ). A critical region particularly vulnerable to environmental insults during ad ...
2024Blunted Glucocorticoid Responsiveness to Stress Causes Behavioral and Biological Alterations That Lead to Posttraumatic Stress Disorder Vulnerability
Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Simone Astori, Sophie Elizabeth Walker, Silvia Monari
Background: Understanding why only a subset of trauma-exposed individuals develop posttraumatic stress disorder is critical for advancing clinical strategies. A few behavioral (deficits in fear extinction) and biological (blunted glucocorticoid levels, sma ...
2023Multivariate patterns of disrupted sleep longitudinally predict affective vulnerability to psychosis in 22q11.2 Deletion Syndrome
Maude Schneider, Farnaz Delavari
22q11.2 deletion syndrome (22q11DS) contributes dramatically to increased genetic risk for psychopathology, and in particular schizophrenia. Sleep disorders, including obstructive sleep apnea (OSA), are also highly prevalent, making 22q11DS a unique model ...
ELSEVIER IRELAND LTD2023Glucocorticoid-based pharmacotherapies preventing PTSD
Maria del Carmen Sandi Perez, Silvia Monari
Posttraumatic stress disorder (PTSD) is a highly disabling psychiatric condition that may arise after exposure to acute and severe trauma. It is a highly prevalent mental disorder worldwide, and the current treatment options for these patients remain limit ...
PERGAMON-ELSEVIER SCIENCE LTD2023Identification of biopsychological trait markers in functional neurological disorders
Weber et al. provide evidence in support of a stress-diathesis model of functional neurological disorders. They identify trauma history in the form of emotional neglect as a psychological risk factor, and reduced hippocampus and amygdala volume as a predis ...
OXFORD UNIV PRESS2022Exploring associations between diurnal cortisol, stress, coping and psychopathology in adolescents and young adults with 22q11.2 deletion syndrome
Maria del Carmen Sandi Perez, Olivia Zanoletti, Maude Schneider, Farnaz Delavari
Background: 22q11.2 deletion syndrome (22q11DS) is a neurogenetic condition associated to a high risk for psychiatric disorders, including psychosis. Individuals with 22q11DS are thought to experience increased levels of chronic stress, which could lead to ...
2022Antibody-Coated Wearable Organic Electrochemical Transistors for Cortisol Detection in Human Sweat
Danick Briand, Marwan El Chazli, Silvia Demuru, Jaemin Kim
The dysregulation of the hormone cortisol is related to several pathological states, and its monitoring could help prevent severe stress, fatigue, and mental diseases. While wearable antibody-based biosensors could allow real-time and simple monitoring of ...
AMER CHEMICAL SOC2022Differential Susceptibility to the Impact of the COVID-19 Pandemic on Working Memory, Empathy, and Perceived Stress: The Role of Cortisol and Resilience
There are important individual differences in adaptation and reactivity to stressful challenges. Being subjected to strict social confinement is a distressful psychological experience leading to reduced emotional well-being, but it is not known how it can ...
2021Contactless Sleep Monitoring for Early Detection of Health Deteriorations in Community-Dwelling Older Adults: Exploratory Study
Daniel Gatica-Perez, Philipp Buluschek, Bruno Pais
Background: Population aging is posing multiple social and economic challenges to society. One such challenge is the social and economic burden related to increased health care expenditure caused by early institutionalizations. The use of modern pervasive ...
JMIR PUBLICATIONS, INC2021Extended gate field-effect-transistor for sensing cortisol stress hormone
Mihai Adrian Ionescu, Junrui Zhang, Sadegh Kamaei Bahmaei, Hoël Maxime Guérin, Luca Capua, Shokoofeh Sheibani, Sayedeh Shirin Afyouni Akbari
Cortisol is a hormone released in response to stress and is a major glucocorticoid produced by adrenal glands. Here, we report a wearable sensory electronic chip using label-free detection, based on a platinum/graphene aptamer extended gate field effect tr ...
SPRINGERNATURE2021