Simple Lie groupIn mathematics, a simple Lie group is a connected non-abelian Lie group G which does not have nontrivial connected normal subgroups. The list of simple Lie groups can be used to read off the list of simple Lie algebras and Riemannian symmetric spaces. Together with the commutative Lie group of the real numbers, , and that of the unit-magnitude complex numbers, U(1) (the unit circle), simple Lie groups give the atomic "blocks" that make up all (finite-dimensional) connected Lie groups via the operation of group extension.
Lie group–Lie algebra correspondenceIn mathematics, Lie group–Lie algebra correspondence allows one to correspond a Lie group to a Lie algebra or vice versa, and study the conditions for such a relationship. Lie groups that are isomorphic to each other have Lie algebras that are isomorphic to each other, but the converse is not necessarily true. One obvious counterexample is and (see real coordinate space and the circle group respectively) which are non-isomorphic to each other as Lie groups but their Lie algebras are isomorphic to each other.
Real form (Lie theory)In mathematics, the notion of a real form relates objects defined over the field of real and complex numbers. A real Lie algebra g0 is called a real form of a complex Lie algebra g if g is the complexification of g0: The notion of a real form can also be defined for complex Lie groups. Real forms of complex semisimple Lie groups and Lie algebras have been completely classified by Élie Cartan. Using the Lie correspondence between Lie groups and Lie algebras, the notion of a real form can be defined for Lie groups.
Enzyme inhibitorAn enzyme inhibitor is a molecule that binds to an enzyme and blocks its activity. Enzymes are proteins that speed up chemical reactions necessary for life, in which substrate molecules are converted into products. An enzyme facilitates a specific chemical reaction by binding the substrate to its active site, a specialized area on the enzyme that accelerates the most difficult step of the reaction.
Enzyme kineticsEnzyme kinetics is the study of the rates of enzyme-catalysed chemical reactions. In enzyme kinetics, the reaction rate is measured and the effects of varying the conditions of the reaction are investigated. Studying an enzyme's kinetics in this way can reveal the catalytic mechanism of this enzyme, its role in metabolism, how its activity is controlled, and how a drug or a modifier (inhibitor or activator) might affect the rate. An enzyme (E) is typically a protein molecule that promotes a reaction of another molecule, its substrate (S).
Lie algebraIn mathematics, a Lie algebra (pronounced liː ) is a vector space together with an operation called the Lie bracket, an alternating bilinear map , that satisfies the Jacobi identity. Otherwise said, a Lie algebra is an algebra over a field where the multiplication operation is now called Lie bracket and has two additional properties: it is alternating and satisfies the Jacobi identity. The Lie bracket of two vectors and is denoted . The Lie bracket does not need to be associative, meaning that the Lie algebra can be non associative.
SerpinSerpins are a superfamily of proteins with similar structures that were first identified for their protease inhibition activity and are found in all kingdoms of life. The acronym serpin was originally coined because the first serpins to be identified act on chymotrypsin-like serine proteases (serine protease inhibitors). They are notable for their unusual mechanism of action, in which they irreversibly inhibit their target protease by undergoing a large conformational change to disrupt the target's active site.
EnzymeEnzymes (ˈɛnzaɪmz) are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyze individual steps.
IC50DISPLAYTITLE:IC50 Half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function. IC50 is a quantitative measure that indicates how much of a particular inhibitory substance (e.g. drug) is needed to inhibit, in vitro, a given biological process or biological component by 50%. The biological component could be an enzyme, cell, cell receptor or microorganism. IC50 values are typically expressed as molar concentration.
ChemotherapyChemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called medical oncology.
