Publication
Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL
Related publications (33)
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EPFL2023Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy caused by acquisition of genetic alterations during T-cell development. The 5-year overall survival of pediatric T-ALL patients has improved considerably over the past 30 ...
EPFL2023Notch1-driven T-ALL chromatin landscape is regulated by Tcf1 in hematopoietic progenitors
Notch1 receptor signaling is essential for T cell fate specification and physiological thymic T lymphocyte development. Its dysregulation and oncogenic activation are detected in almost 80% of pediatric patients suffering from T cell acute lymphoblastic le ...
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NOTCH1 gain-of-function mutations are recurrent in B-cell chronic lymphocytic leukemia (B-CLL), where they are associated with accelerated disease progression and refractoriness to chemotherapy. The specific role of NOTCH1 in the development and progressio ...
AMER SOC HEMATOLOGY2021Notch Signaling - a Booster of Chronic Lymphocytic Leukemia During Initiation and Disease Progression
Chronic lymphocytic leukemia (CLL) is a B cell malignancy and represents the most common leukemia in adults within the Western world. This disease mainly affects the elderly, with a median age of diagnosis over 70. The disease course is highly variable amo ...
EPFL2020Characterization of myelodysplastic syndromes progressing to acute lymphoblastic leukemia
Filipe Amândio Brandão Sanches Vong Martins
Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases, with a variable probability of transformation into acute leukemia, which is, in the vast majority of cases, of myeloid lineage. Nevertheless, rare cases of acute lymphoblastic leukemia ...
SPRINGER2020The nuclear receptor corepressor NCoR1 regulates hematopoiesis and leukemogenesis in vivo
Johan Auwerx, Lulu Liu, Wei Zhang, Yao Zhang, Na Zhang
Enhanced understanding of normal and malignant hematopoiesis pathways should facilitate the development of effective clinical treatment strategies for hematopoietic malignancies. Nuclear receptor corepressor 1 (NCoR1) has been implicated in transcriptional ...
AMER SOC HEMATOLOGY2019Histone Modifications in Development and Malignancy
Non-Hodgkin lymphoma (NHL) development is driven by the accumulations of multiple genetic, epigenetic, and chromosomal alterations. These lesions can lead to modifications of the chromatin architecture. To identify novel oncogenic interactions driven by mo ...
AMER SOC HEMATOLOGY2019γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia
Oliver Hantschel, Anja Irmisch
The BCR-ABL1 fusion protein is the cause of chronic myeloid leukemia (CML) and of a significant fraction of adult-onset B cell acute lymphoblastic leukemia (B-ALL) cases. Using mouse models and patient-derived samples, we identified an essential role for γ ...
2019