Publications related to The interplay between human genetic variation, chronic inflammation and persistent infection: relevance for cardiovascular morbidity

Determinants of HIV-1 broadly neutralizing antibody induction

Jacques Fellay, Christian Axel Wandall Thorball

Broadly neutralizing antibodies (bnAbs) are a focal component of HIV-1 vaccine design, yet basic aspects of their induction remain poorly understood. Here we report on viral, host and disease factors that steer bnAb evolution using the results of a systema ...

Nature Publishing Group2016

Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses

Jacques Fellay, Istvan Bartha, Christian Hammer

The magnitude of the human antibody response to viral antigens is highly variable. To explore the human genetic contribution to this variability, we performed genome-wide association studies of the immunoglobulin G response to 14 pathogenic viruses in 2,36 ...

Cell Press2015

Human genetic variation in HIV disease: beyond genome-wide association studies

Jacques Fellay

PURPOSE OF REVIEW: Rapid expansion of genomic technologies has resulted in an unprecedented ability to interrogate the impact of human genetic variation on disease. HIV-1 infection is a unique model for studying this impact because host genetic variation i ...

Lippincott Williams & Wilkins2015

The Interplay Between Host Genetic Variation, Viral Replication, and Microbial Translocation in Untreated HIV-Infected Individuals

Jacques Fellay, Amalio Telenti, Istvan Bartha

Systemic immune activation, a major determinant of human immunodeficiency virus (HIV) disease progression, is the result of a complex interplay between viral replication, dysregulation of the immune system, and microbial translocation due to gut mucosal da ...

Oxford University Press2015

Limits and patterns of cytomegalovirus genomic diversity in humans

Jeffrey David Jensen, Cornelia Pokalyuk

Human cytomegalovirus (HCMV) exhibits surprisingly high genomic diversity during natural infection although little is known about the limits or patterns of HCMV diversity among humans. To address this deficiency, we analyzed genomic diversity among congeni ...

Natl Acad Sciences2015

Ultrafast laser ablation for targeted atherosclerotic plaque removal

Demetri Psaltis, Donald Benjaman Conkey, Thomas Jean Victor Marie Lanvin, Laurent Descloux

Coronary artery disease, the main cause of heart disease, develops as immune cells and lipids accumulate into plaques within the coronary arterial wall. As a plaque grows, the tissue layer (fibrous cap) separating it from the blood flow becomes thinner and ...

Spie-Int Soc Optical Engineering2015

Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence

Bruno Lemaitre, Bart Deplancke, Andreas Massouras, Maroun Bou Sleiman, Dani Osman

Gut immunocompetence involves immune, stress and regenerative processes. To investigate the determinants underlying inter-individual variation in gut immunocompetence, we perform enteric infection of 140 Drosophila lines with the entomopathogenic bacterium ...

Nature Publishing Group2015

Detection of Convergent Genome-Wide Signals of Adaptation to Tropical Forests in Humans

Matthieu Foll

Tropical forests are believed to be very harsh environments for human life. It is unclear whether human beings would have ever subsisted in those environments without external resources. It is therefore possible that humans have developed recent biological ...

Public Library of Science2015

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The interplay between human genetic variation, chronic inflammation and persistent infection: relevance for cardiovascular morbidity

Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

Determinants of HIV-1 broadly neutralizing antibody induction

Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses

Human genetic variation in HIV disease: beyond genome-wide association studies

The Interplay Between Host Genetic Variation, Viral Replication, and Microbial Translocation in Untreated HIV-Infected Individuals

Limits and patterns of cytomegalovirus genomic diversity in humans

Ultrafast laser ablation for targeted atherosclerotic plaque removal

Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence

Detection of Convergent Genome-Wide Signals of Adaptation to Tropical Forests in Humans

Leben und sterben lassen – horizontaler Gentransfer in Vibrio cholerae

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Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

Ultrafast laser ablation for targeted atherosclerotic plaque removal

Determinants of HIV-1 broadly neutralizing antibody induction

Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses

Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence

The Interplay Between Host Genetic Variation, Viral Replication, and Microbial Translocation in Untreated HIV-Infected Individuals

Leben und sterben lassen – horizontaler Gentransfer in Vibrio cholerae

Human genetic variation in HIV disease: beyond genome-wide association studies

Limits and patterns of cytomegalovirus genomic diversity in humans

Detection of Convergent Genome-Wide Signals of Adaptation to Tropical Forests in Humans