Liver cancerLiver cancer (also known as hepatic cancer, primary hepatic cancer, or primary hepatic malignancy) is cancer that starts in the liver. Liver cancer can be primary (starts in liver) or secondary (meaning cancer which has spread from elsewhere to the liver, known as liver metastasis). Liver metastasis is more common than that which starts in the liver. Liver cancer is increasing globally. Primary liver cancer is globally the sixth-most frequent cancer and the fourth-leading cause of death from cancer.
Cell fractionationIn cell biology, cell fractionation is the process used to separate cellular components while preserving individual functions of each component. This is a method that was originally used to demonstrate the cellular location of various biochemical processes. Other uses of subcellular fractionation is to provide an enriched source of a protein for further purification, and facilitate the diagnosis of various disease states. Tissue is typically homogenized in a buffer solution that is isotonic to stop osmotic damage.
DayA day is the time period of a full rotation of the Earth with respect to the Sun. On average, this is 24 hours (86,400 seconds). As a day passes at a given location it experiences morning, noon, afternoon, evening, and night. This daily cycle drives circadian rhythms in many organisms, which are vital to many life processes. A collection of sequential days is organized into calendars as dates, almost always into weeks, months and years. A solar calendar organizes dates based on the Sun's annual cycle, giving consistent start dates for the four seasons from year to year.
ExomeThe exome is composed of all of the exons within the genome, the sequences which, when transcribed, remain within the mature RNA after introns are removed by RNA splicing. This includes untranslated regions of messenger RNA (mRNA), and coding regions. Exome sequencing has proven to be an efficient method of determining the genetic basis of more than two dozen Mendelian or single gene disorders. The human exome consists of roughly 233,785 exons, about 80% of which are less than 200 base pairs in length, constituting a total of about 1.
Exosome complexThe exosome complex (or PM/Scl complex, often just called the exosome) is a multi-protein intracellular complex capable of degrading various types of RNA (ribonucleic acid) molecules. Exosome complexes are found in both eukaryotic cells and archaea, while in bacteria a simpler complex called the degradosome carries out similar functions. The core of the exosome contains a six-membered ring structure to which other proteins are attached.
NightNight (also described as nighttime, unconventionally spelled as "nite") is the period of ambient darkness from sunset to sunrise during each 24-hour day, when the Sun is below the horizon. The exact time when night begins and ends depends on the location and varies throughout the year, based on factors such as season and latitude. The word can be used in a different sense as the time between bedtime and morning. In common communication, it is a farewell (sometimes lengthened to "good night"), mainly when someone is going to sleep or leaving.
