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Low-Intensity Electrostimulation Enhances Neuroregeneration and Improves Erectile Function in a Rat Model of Cavernous Nerve Injury

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Osteoarthritis (OA) is one of the most common causes of pain and disability. Currently, non-surgical treatment is limited to analgesic and anti-inflammatory drugs, which are not capable of either modifying the disease process or regenerate damaged parts in ...

EPFL2009

Mammalian target of rapamycin (mTOR), a highly conserved protein kinase that controls cell growth and metabolism in response to nutrients and growth factors, is found in 2 structurally and functionally distinct multiprotein complexes termed mTOR complex 1 ...

2009

Interstitial fluid flow, critical for macromolecular transport, was recently shown to drive fibroblast differentiation and perpendicular cell and matrix alignment in 3D collagen cultures. Here we explore the mechanisms underlying this flow-induced cell and ...

Springer US2006

Geometrical, functional, and histomorphometric adaptation of rat carotid artery in induced hypertension

Nikolaos Stergiopoulos, Martin Zulliger

Acute and long-term (up to 56 days) evolution of geometry, structural properties, vascular smooth muscle (VSM) tone and histomorphometric properties of the rat common carotid arteries under induced hypertension were investigated. Hypertension was induced i ...

2003

It is presently accepted that fibroblast/myofibroblast modulation represents a crucial step in granulation tissue contraction and in the production of the connective tissue deformations typical of fibrocontractive diseases. In addition to synthesizing extr ...

Schattauer2003

GDNF and NGF released by synthetic guidance channels support sciatic nerve regeneration across a long gap

Patrick Aebischer, Eric Garrison Fine

The present work was performed to determine the ability of neurotrophic factors to allow axonal regeneration across a 15-mm-long gap in the rat sciatic nerve. Synthetic nerve guidance channels slowly releasing NGF and GDNF were fabricated and sutured to th ...

2002

Regeneration of the human facial nerve after lesion is often limited, leading to severe functional impairments, in particular when repair is delayed for several months, when cross-facial nerve grafts have to be performed, or in elderly patients. To improve ...

2002

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Dorsal roots have a limited regeneration capacity after transection. To improve nerve regeneration, the growth-promoting effects of the neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) were evalua ...

2001

Development of novel growth factor fusion proteins with exogenous immobilization domains for cellularly controlled drug delivery

Jeffrey Alan Hubbell

A novel method for the delivery of growth factor proteins from fibrin matrixes was developed. Nerve growth factor (NGF) fusion proteins contg. an exogenous transglutaminase substrate at the N-terminus of the protein were made recombinantly by E. coli. The ...

2000

Controlled release of nerve growth factor from a heparin-containing fibrin-based cell ingrowth matrix

Jeffrey Alan Hubbell

The goal of this work was to develop a growth factor delivery system for use in nerve regeneration that would provide localized release of beta-nerve growth factor (b-NGF) and other members of the neurotrophin family in a controlled manner. Although b-NGF ...

2000