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The aging brain as a model to understand motor skill acquisition in humans and its restoration using non-invasive brain stimulation

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Spinal cord injury (SCI) is the second leading cause of paralysis, which induces abrupt impairments with devastating consequences for the quality of life of patients. Despite significant progress in SCI treatment through neurorehabilitation training and sp ...

EPFL2017

Physiological aging is paralleled by a decline of fine motor skills accompanied by structural and functional alterations of the underlying brain network. Here, we aim to investigate age-related changes in the spectral distribution of neuronal oscillations ...

2016

Differential effects of BDNF val(66)met in repetitive associative learning paradigms

Friedhelm Christoph Hummel, Winifried Backhaus

In healthy young subjects, the brain derived neurotropic factor (BDNF) val(66)met polymorphism negatively affects behavioural outcome in short-term motor cortex or hippocampus-based learning paradigms. In repetitive training paradigms over several days thi ...

Elsevier2015

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Non-invasive brain stimulation has shown promis- ing results in neurorehabilitation for motor-impaired stroke patients, by rebalancing the relative involvement of each hemisphere in movement generation. Similarly, brain-computer interfaces have been used t ...

2015

Brain-Machine Interfaces: The Perception-Action Closed Loop

José del Rocio Millán Ruiz

A brain-machine interface (BMI) is about transforming neural activity into action and sensation into perception (Figure 1). In a BMI system, neural signals recorded from the brain are fed into a decoding algorithm that translates these signals into motor o ...

2015

Connectivity Analysis of Brain States and Applications in Brain-Computer Interfaces

Huaijian Zhang

Human brain is organized by a large number of functionally correlated but spatially distributed cortical neurons. Cognitive processes are usually associated with dynamic interactions among multiple brain regions. Therefore, the understanding of brain funct ...

EPFL2015

Neurotechnology is the application of scientific knowledge to the practical purpose of understanding, interacting and/or repairing the brain or, in a broader sense, the nervous system. The development of novel approaches to decode functional information fr ...

EPFL2014

White matter integrity of motor connections related to training gains in healthy aging

Friedhelm Christoph Hummel, Maximilian Jonas Wessel

Impaired motor skill acquisition is a feature of older age. Acquisition of new motor skills requires the interplay between different cortical motor areas. Using diffusion tensor imaging we reconstructed cortico-cortical connections between the primary moto ...

Elsevier2014

Optimized MEGA-SPECIAL for in vivo glutamine detection in the rat brain at 14.1 T

Rolf Gruetter, Cristina Ramona Cudalbu, Mélanie Craveiro

Glutamine has multiple roles in brain metabolism and its concentration can be altered in various pathological conditions. An accurate knowledge of its concentration is therefore highly desirable to monitor and study several brain disorders in vivo. However ...

Wiley-Blackwell2014

The brain has very high energy demands that are mainly met by the circulating blood glucose to ensure its proper functioning. Thus, it is not surprising that though the human brain weighs only 2- 3% of the body weight, it consumes approximately 25% of tota ...

EPFL2013