Publication
Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis
Related publications (155)
Expression of E-Cadherin in Epithelial Cancer Cells Increases Cell Motility and Directionality through the Localization of ZO-1 during Collective Cell Migration
Collective cell migration of epithelial tumor cells is one of the important factors for elucidating cancer metastasis and developing novel drugs for cancer treatment. Especially, new roles of E-cadherin in cancer migration and metastasis, beyond the epithe ...
MDPI2021Engineered Extracellular Matrices with Integrated Wireless Microactuators to Study Mechanobiology
Mahmut Selman Sakar, Erik Mailand, Nikolaos Bouklas, Fazil Emre Uslu
Mechanobiology explores how forces regulate cell behaviors and what molecular machinery are responsible for the sensing, transduction, and modulation of mechanical cues. To this end, probing of cells cultured on planar substrates has served as a primary ex ...
2021Structural basis of Focal Adhesion Kinase activation on lipid membranes
Henning Paul-Julius Stahlberg, Frauke Gräter
Focal adhesion kinase (FAK) is a key component of the membrane proximal signaling layer in focal adhesion complexes, regulating important cellular processes, including cell migration, proliferation, and survival. In the cytosol, FAK adopts an autoinhibited ...
2020Receptor-independent modulation of cAMP-dependent protein kinase and protein phosphatase signaling in cardiac myocytes by oxidizing agents
The contraction and relaxation of the heart is controlled by stimulation of the beta 1-adrenoreceptor (AR) signaling cascade, which leads to activation of cAMP-dependent protein kinase (PKA) and subsequent cardiac protein phosphorylation. Phosphorylation i ...
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC2020Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation
Suliana Manley, Christian Sieben
Influenza A virus (IAV) binds its host cell using the major viral surface protein hemagglutinin (HA). HA recognizes sialic acid, a plasma membrane glycan that functions as the specific primary attachment factor (AF). Since sialic acid alone cannot fulfill ...
2020Multi-color Molecular Visualization of Signaling Proteins Reveals How C-Terminal Src Kinase Nanoclusters Regulate T Cell Receptor Activation
Elucidating the mechanisms that controlled T cell activation requires visualization of the spatial organization of multiple proteins on the submicron scale. Here, we use stoichiometrically accurate, multiplexed, single-molecule super-resolution microscopy ...
CELL PRESS2020TBX3 acts as tissue-specific component of the Wnt/beta-catenin transcriptional complex
Michel Aguet, Andreas Eduard Moor
BCL9 and PYGO are beta-catenin cofactors that enhance the transcription of Wnt target genes. They have been proposed as therapeutic targets to diminish Wnt signaling output in intestinal malignancies. Here we find that, in colorectal cancer cells and in de ...
ELIFE SCIENCES PUBLICATIONS LTD2020Precision Targeting of pten-Null Triple-Negative Breast Tumors Guided by Electrophilic Metabolite Sensing
Yimon Aye, Xuyu Liu, Lingxi Wang, Chaosheng Luo
Off-target effects continue to impede disease interventions, particularly when targeting a specific protein within a family of similar proteins, such as kinase isoforms that play tumor-subtype-specific roles in cancers. Exploiting the specific electrophili ...
AMER CHEMICAL SOC2020Transmembrane Prolines Mediate Signal Sensing and Decoding in Bacillus subtilis DesK Histidine Kinase
Matteo Dal Peraro, Luciano Andres Abriata
Environmental awareness is an essential attribute of all organisms. The homeoviscous adaptation system of Bacillus subtilis provides a powerful experimental model for the investigation of stimulus detection and signaling mechanisms at the molecular level. ...
American Society for Microbiology2019Detection of dicistroviruses RNA in blood of febrile Tanzanian children
Mary-Anne Hartley, Thomas Junier
Fever is the leading cause of paediatric outpatient consultations in Sub-Saharan Africa. Although most are suspected to be of viral origin, a putative causative pathogen is not identified in over a quarter of these febrile episodes. Using a de novo assembl ...
TAYLOR & FRANCIS LTD2019