Strategies to Functionalize the Anionic Biopolymer Na-Alginate Without Restricting its Polyelectrolyte Properties

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Synthesis strategies to extend the variety of alginate-based hybrid hydrogels for cell microencapsulation

Sandrine Gerber, François Rémi Pierre Noverraz, Jutta Christine Wandrey, Luca Szabó, Solène Marcelle Françoise Marie Passemard

The production of hydrogel microspheres (MS) for cell immobilization, maintaining the favorable properties of alginate gels but presenting enhanced performance in terms of in vivo durability and physical properties, is desirable to extend the therapeutic p ...

American Chemical Society2017

Nano Fibrillated Cellulose Based Composite Hydrogels for an Injectable Intervertebral Disc Implant

Azadeh Khoushabi

Replacing the gel-like central part of the intervertebral disc (IVD), so-called nucleus pulposus (NP), via a minimally invasive surgery is one of the most recent approaches in the lower back pain treatments. An appropriate biomaterial for NP replacement (N ...

EPFL2016

Functionalized Ionic (Poly)Styrenes and their Application as Catalysts in the Cycloaddition of CO2 to Epoxides

Paul Joseph Dyson, Rosario Scopelliti, Zhaofu Fei, Felix Daniel Bobbink, Shoubhik Das

Valorization of CO2, an abundant C(1) synthon, into platform chemicals is of growing interest. In this context, a key reaction is the cycloaddition of CO2 to epoxides to form carbonates (CCE). A series of organocatalysts for this reaction, based on imidazo ...

Wiley-Blackwell2016

Tuning the Properties of Hydrogel Microspheres by Adding Chemical Cross-linking Functionality to Sodium Alginate

Sandrine Gerber, Jutta Christine Wandrey, François Rémi Pierre Noverraz, Solène Marcelle Françoise Marie Passemard, Redouan Mahou, Françoise Borcard, Virginia Crivelli, Léo Bühler

Two novel types of hydrogel microspheres (MS) are presented. First, one-component microspheres (1-comMS) were produced from sodium alginate (Na-alg) equipped with thiolfunctionalized hydroxyl groups. The functionalization pathway included the conversion of ...

American Chemical Society2015

Microfluidic patterning of alginate hydrogels

Philippe Renaud

In this article the authors present techniques which allow the microfluidic design of alginate microgels with layer composition on a chip. The hydrogel is created by combining two laminar flows of the gel precursor solutions-a calcium solution and an algin ...

American Vacuum Society2007

Alginate-based microcapsules for mammalian cell culture and other biotechnological applications

Véronique Breguet

Since life began, nature has been using the envelopment of systems for their protection or for providing a particular reaction space, the enveloping wall displaying additional specific membrane functions. The abundance of examples is quite overwhelming and ...

EPFL2007

Gentle cell trapping and release on a microfluidic chip by in situ alginate hydrogel formation

Philippe Renaud, Thomas Michael Braschler, Lynda Metref

Microfluidic devices are increasingly used to perform biological experiments on a single-cell basis. However, long-term stability of cell positions is still an issue. A novel biocompatible method for cell entrapment and release on a microchip is presented. ...

2005

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