Bile Acids Increase Levels of MicroRNAs 221 and 222, Leading to Degradation of CDX2 During Esophageal Carcinogenesis

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Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents

A large number of glucagon-like-peptide-1(GLP-1)- and peptide-YY (PYY)-producing L cells are located in the colon, but little is known about their contribution to whole body metabolism. Since bile acids (BAs) increase GLP-1 and PYY release, and since BAs s ...

AMER PHYSIOLOGICAL SOC2019

The G Protein-Coupled Bile Acid Receptor TGR5 (Gpbar1) Modulates Endothelin-1 Signaling in Liver

Kristina Schoonjans

TGR5 (Gpbar1) is a G protein-coupled receptor responsive to bile acids (BAs), which is expressed in different non-parenchymal cells of the liver, including biliary epithelial cells, liver-resident macrophages, sinusoidal endothelial cells (LSECs), and acti ...

2019

D35-TiO2 nano-crystalline film as a high performance visible-light photocatalyst towards the degradation of bis-phenol A

Ulf Anders Hagfeldt, Lin Yang, Xue Bai

Dye-sensitized photocatalytic suspension system for wastewater treatment is still limited in practice due to particle aggregation, fast charge carrier recombination, poor stability and recycling issue. In this study, we combine TiO2 nano-crystalline film w ...

ELSEVIER SCIENCE SA2019

Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human beta-defensin-1 and-2 secretion by colonic epithelial cells

Kristina Schoonjans, Alessia Perino

Bile acids and epithelial-derived human beta-defensins (H beta Ds) are known to be important factors in the regulation of colonic mucosal barrier function and inflammation. We hypothesized that bile acids regulate colonic H beta D expression and aimed to t ...

Federation of American Society of Experimental Biology2017

beta-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue

Kristina Schoonjans

beta-Klotho (encoded by Klb) is the obligate coreceptor mediating FGF21 and FGF15/19 signaling. Klb(-/-)mice are refractory to beneficial action of pharmacological FGF21 treatment including stimulation of glucose utilization and thermogenesis. Here, we inv ...

Amer Soc Clinical Investigation Inc2017

The microbiota provides colonisation resistance against intestinal helminths by regulating intestinal physiology

Luc Xavier Marie Lebon

Intestinal helminth infections are a global health problem affecting particularly people living in poor countries. Heavy worm burdens can lead to nutritional and cognitive deficiencies. Type-two immunity plays a crucial role in promoting tissue repair and ...

EPFL2017

Polyphenic trait promotes liver cancer in a model of epigenetic instability

Didier Trono, Sandra Eloise Kjeldsen, Marco Cassano, Suk Min Jang, Evaristo Jose Planet Letschert, Alessandra Piersigilli

Hepatocellular carcinoma (HCC) represents the fifth most common form of cancer worldwide and carries a high mortality rate due to lack of effective treatment. Males are eight times more likely to develop HCC than females, an effect largely driven by sex ho ...

Wiley-Blackwell2017

Small Heterodimer Partner Deletion Prevents Hepatic Steatosis and When Combined With Farnesoid X Receptor Loss Protects Against Type 2 Diabetes in Mice

Kristina Schoonjans

Nuclear receptors farnesoid X receptor (FXR) and small heterodimer partner (SHP) are important regulators of bile acid, lipid, and glucose homeostasis. Here, we show that global Fxr(-/-) Shp(-/-) double knockout (DKO) mice are refractory to weight gain, gl ...

Wiley2017

Plasma Membrane-bound G Protein-coupled Bile Acid Receptor Attenuates Liver Ischemia/Reperfusion Injury Via the Inhibition of Toll-like Receptor 4 Signaling in Mice

Johan Auwerx, Kristina Schoonjans, Xu Wang

The plasma membrane-bound G protein-coupled bile acid receptor (TGR5) displays varied levels of expression in different tissues. TGR5-induced liver protection has been demonstrated during several liver diseases, except during ischemia/reperfusion injury (I ...

Wiley2017

Synchronic coupling of Cu2O(p)/CuO(n) semiconductors leading to Norfloxacin degradation under visible light: Kinetics, mechanism and film surface properties

César Pulgarin, Juan Kiwi, Sami Rtimi, Michaël Bensimon, Gcina Mamba

The study presents the first evidence for Norfoxacin photodegradation by uniform, adhesive and robust CuOx-polystyrene (CuOx-PES) films under visible light. Repetitive Norfloxacin degradation was attained on CuOx-PES films activated by visible light. The s ...

Elsevier2017

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Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human beta-defensin-1 and-2 secretion by colonic epithelial cells

Kristina Schoonjans, Alessia Perino

Federation of American Society of Experimental Biology2017

Small Heterodimer Partner Deletion Prevents Hepatic Steatosis and When Combined With Farnesoid X Receptor Loss Protects Against Type 2 Diabetes in Mice

Kristina Schoonjans

Wiley2017

Synchronic coupling of Cu2O(p)/CuO(n) semiconductors leading to Norfloxacin degradation under visible light: Kinetics, mechanism and film surface properties

César Pulgarin, Juan Kiwi, Sami Rtimi, Michaël Bensimon, Gcina Mamba

Elsevier2017

Plasma Membrane-bound G Protein-coupled Bile Acid Receptor Attenuates Liver Ischemia/Reperfusion Injury Via the Inhibition of Toll-like Receptor 4 Signaling in Mice

Johan Auwerx, Kristina Schoonjans, Xu Wang

Wiley2017