Publications related to Biodegradable Implantable Microsystems

Extracellular Matrix Production by Mesenchymal Stromal Cells in Hydrogels Facilitates Cell Spreading and Is Inhibited by FGF-2

In native tissues, the interaction between cells and the surrounding extracellular matrix (ECM) is reciprocal, as cells not only receive signals from the ECM but also actively remodel it through secretion of cell-derived ECM. However, very little is known ...

2020

Mechanoresponsive Micro- and Nanoparticles

Harm-Anton Klok, Friederike Katharina Metze

Mechanical stimuli are ubiquitous in the human body. In contrast to biochemical stimuli such as pH, redox, hypoxia or enzymes as well as exogenous stimuli such as magnetic fields, temperature or ultrasound, endogenous biomechanical stimuli have only receiv ...

2019

A Gauss-Bonnet Theorem for Asymptotically Conical Manifolds and Manifolds with Conical Singularities

Adrien Giuliano Marcone

The purpose of this thesis is to provide an intrinsic proof of a Gauss-Bonnet-Chern formula for complete Riemannian manifolds with finitely many conical singularities and asymptotically conical ends. A geometric invariant is associated to the link of both ...

EPFL2019

Escaping from saddle points on Riemannian manifolds

Nicolas Henri Bernard Flammarion, Yue Sun

We consider minimizing a nonconvex, smooth function f on a Riemannian manifold M. We show that a perturbed version of Riemannian gradient descent algorithm converges to a second-order stationary point (and hence is able to escape saddle points on the manif ...

2019

Improved Bounds for Discretization of Langevin Diffusions: Near-Optimal Rates without Convexity

Nicolas Henri Bernard Flammarion

We consider minimizing a nonconvex, smooth function

f

on a Riemannian manifold

\mathcal{M}

. We show that a perturbed version of Riemannian gradient descent algorithm converges to a second-order stationary point (and hence is able to escape saddle point ...

2019

Implementation of Functional Microfluidic Dispensing Tools Enabling Enhanced Control in Extrusion Bioprinting

Ludovic Serex

Inspired from additive manufacturing's success, the structuring of biocompatible materials through bioprinting has become a growing field of research in the past fifteen years. It opened the door to a plethora of applications ranging from the fabrication o ...

EPFL2019

Additive manufacturing of hierarchical injectable scaffolds for tissue engineering

Philippe Renaud, Niccolo Piacentini, Thomas Michael Braschler, Ariane Rochat

We present a 3D-printing technology allowing free-form fabrication of centimetre-scale injectable structures for minimally invasive delivery. They result from the combination of 3D printing onto a cryogenic substrate and optimisation of carboxymethylcellul ...

2018

Shapeable scaffold material and uses thereof

Philippe Renaud, Thomas Michael Braschler, Amélie Barbara Hildegarde Béduer, Giorgio Pietramaggiori

The invention relates to a scaffold material comprising a plurality of particles of a highly porous polymeric material, characterized in that said scaffold material becomes a shapeable paste once hydrated. The specific features of the particle material imp ...

2017

Geometric deep learning: going beyond Euclidean data

Pierre Vandergheynst, Michael Bronstein

Many signal processing problems involve data whose underlying structure is non-Euclidean, but may be modeled as a manifold or (combinatorial) graph. For instance, in social networks, the characteristics of users can be modeled as signals on the vertices of ...

2017

Tunable and cell-responsive 3D poly(ethylene glycol) microenvironments for the development of tissue models

Stéphanie Elisabeth Metzger

The recapitulation of tissue organization and function in vitro is one of the main objectives of tissue engineering. Proper tissue function depends on the spatial assembly and interactions between key components such as cells, growth factors, signaling cue ...

EPFL2016

Biodegradable Implantable Microsystems

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Extracellular Matrix Production by Mesenchymal Stromal Cells in Hydrogels Facilitates Cell Spreading and Is Inhibited by FGF-2

Mechanoresponsive Micro- and Nanoparticles

A Gauss-Bonnet Theorem for Asymptotically Conical Manifolds and Manifolds with Conical Singularities

Escaping from saddle points on Riemannian manifolds

Improved Bounds for Discretization of Langevin Diffusions: Near-Optimal Rates without Convexity

Implementation of Functional Microfluidic Dispensing Tools Enabling Enhanced Control in Extrusion Bioprinting

Additive manufacturing of hierarchical injectable scaffolds for tissue engineering

Shapeable scaffold material and uses thereof

Geometric deep learning: going beyond Euclidean data

Tunable and cell-responsive 3D poly(ethylene glycol) microenvironments for the development of tissue models

Improved Bounds for Discretization of Langevin Diffusions: Near-Optimal Rates without Convexity

Tunable and cell-responsive 3D poly(ethylene glycol) microenvironments for the development of tissue models

A Gauss-Bonnet Theorem for Asymptotically Conical Manifolds and Manifolds with Conical Singularities

Implementation of Functional Microfluidic Dispensing Tools Enabling Enhanced Control in Extrusion Bioprinting

Escaping from saddle points on Riemannian manifolds

Additive manufacturing of hierarchical injectable scaffolds for tissue engineering

Shapeable scaffold material and uses thereof

Mechanoresponsive Micro- and Nanoparticles

Extracellular Matrix Production by Mesenchymal Stromal Cells in Hydrogels Facilitates Cell Spreading and Is Inhibited by FGF-2

Geometric deep learning: going beyond Euclidean data