ChromatinChromatin is a complex of DNA and protein found in eukaryotic cells. The primary function is to package long DNA molecules into more compact, denser structures. This prevents the strands from becoming tangled and also plays important roles in reinforcing the DNA during cell division, preventing DNA damage, and regulating gene expression and DNA replication. During mitosis and meiosis, chromatin facilitates proper segregation of the chromosomes in anaphase; the characteristic shapes of chromosomes visible during this stage are the result of DNA being coiled into highly condensed chromatin.
Chromatin remodelingChromatin remodeling is the dynamic modification of chromatin architecture to allow access of condensed genomic DNA to the regulatory transcription machinery proteins, and thereby control gene expression. Such remodeling is principally carried out by 1) covalent histone modifications by specific enzymes, e.g., histone acetyltransferases (HATs), deacetylases, methyltransferases, and kinases, and 2) ATP-dependent chromatin remodeling complexes which either move, eject or restructure nucleosomes.
Topologically associating domainA topologically associating domain (TAD) is a self-interacting genomic region, meaning that DNA sequences within a TAD physically interact with each other more frequently than with sequences outside the TAD. The median size of a TAD in mouse cells is 880 kb, and they have similar sizes in non-mammalian species. Boundaries at both side of these domains are conserved between different mammalian cell types and even across species and are highly enriched with CCCTC-binding factor (CTCF) and cohesin.
TriangleA triangle is a polygon with three edges and three vertices. It is one of the basic shapes in geometry. A triangle with vertices A, B, and C is denoted . In Euclidean geometry, any three points, when non-collinear, determine a unique triangle and simultaneously, a unique plane (i.e. a two-dimensional Euclidean space). In other words, there is only one plane that contains that triangle, and every triangle is contained in some plane.
Medial triangleIn Euclidean geometry, the medial triangle or midpoint triangle of a triangle △ABC is the triangle with vertices at the midpoints of the triangle's sides AB, AC, BC. It is the n = 3 case of the midpoint polygon of a polygon with n sides. The medial triangle is not the same thing as the median triangle, which is the triangle whose sides have the same lengths as the medians of △ABC. Each side of the medial triangle is called a midsegment (or midline). In general, a midsegment of a triangle is a line segment which joins the midpoints of two sides of the triangle.
Isosceles triangleIn geometry, an isosceles triangle (aɪˈsɒsəliːz) is a triangle that has two sides of equal length. Sometimes it is specified as having exactly two sides of equal length, and sometimes as having at least two sides of equal length, the latter version thus including the equilateral triangle as a special case. Examples of isosceles triangles include the isosceles right triangle, the golden triangle, and the faces of bipyramids and certain Catalan solids.
ProphaseProphase () is the first stage of cell division in both mitosis and meiosis. Beginning after interphase, DNA has already been replicated when the cell enters prophase. The main occurrences in prophase are the condensation of the chromatin reticulum and the disappearance of the nucleolus. Microscopy can be used to visualize condensed chromosomes as they move through meiosis and mitosis. Various DNA stains are used to treat cells such that condensing chromosomes can be visualized as the move through prophase.
Nuclear laminaThe nuclear lamina is a dense (~30 to 100 nm thick) fibrillar network inside the nucleus of eukaryote cells. It is composed of intermediate filaments and membrane associated proteins. Besides providing mechanical support, the nuclear lamina regulates important cellular events such as DNA replication and cell division. Additionally, it participates in chromatin organization and it anchors the nuclear pore complexes embedded in the nuclear envelope.
Pons asinorumIn geometry, the statement that the angles opposite the equal sides of an isosceles triangle are themselves equal is known as the pons asinorum (ˈpõːs asɪˈnoːrũː, ˈpɒnz_ˌaesᵻˈnɔərəm ), typically translated as "bridge of asses". This statement is Proposition 5 of Book 1 in Euclid's Elements, and is also known as the isosceles triangle theorem. Its converse is also true: if two angles of a triangle are equal, then the sides opposite them are also equal. The term is also applied to the Pythagorean theorem.
Topological quantum numberIn physics, a topological quantum number (also called topological charge) is any quantity, in a physical theory, that takes on only one of a discrete set of values, due to topological considerations. Most commonly, topological quantum numbers are topological invariants associated with topological defects or soliton-type solutions of some set of differential equations modeling a physical system, as the solitons themselves owe their stability to topological considerations.
