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Computational Concepts for Reconstructing and Simulating Brain Tissue

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The Scientific Case for Brain Simulations

Felix Schürmann, Michele Migliore, Alain Destexhe

A key element of the European Union's Human Brain Project (HBP) and other large-scale brain research projects is the simulation of large-scale model networks of neurons. Here, we argue why such simulations will likely be indispensable for bridging the scal ...

CELL PRESS2019

A Brief History of Simulation Neuroscience

Henry Markram, Xue Fan

Our knowledge of the brain has evolved over millennia in philosophical, experimental and theoretical phases. We suggest that the next phase is simulation neuroscience. The main drivers of simulation neuroscience are big data generated at multiple levels of ...

FRONTIERS MEDIA SA2019

Dynamic organization of human brain function and its relevance for psychosis vulnerability

Daniela Maria Zöller

The brain is the substrate of a complex dynamic system providing a remarkably varied range of functionalities, going from simple perception to higher-level cognition. Disturbances in its complex dynamics can cause an equally vast variety of mental disorder ...

EPFL2019

Cell Densities in the Mouse Brain: A Systematic Review

Henry Markram, Daniel Keller, Csaba Erö

The mouse brain is the most extensively studied brain of all species. We performed an exhaustive review of the literature to establish our current state of knowledge on cell numbers in mouse brain regions, arguably the most fundamental property to measure ...

FRONTIERS MEDIA SA2018

In this work, we present a semi-automatic method to reconstruct a mouse whole-brain model at the point-neuron level by integrating a wide array of biological data. Our process has three parts: cell position and type assignment, connectivity mapping, and si ...

EPFL2018

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One will not understand the brain without an integrated exploration of structure and function, these attributes being two sides of the same coin: together they form the currency of biological computation. Accordingly, biologically realistic models require ...

2018

While several studies have shown that focal lesions affect the communication between structurally normal regions of the brain, and that these changes may correlate with behavioural deficits, their impact on brain's information processing capacity is curren ...

Oxford Univ Press2017

Distributed Patterns of Brain Activity Underlying Real-Time fMRI Neurofeedback Training

Dimitri Nestor Alice Van De Ville, Frank Scharnowski, Kirsten Emmert, Rotem Roza Kopel

Neurofeedback (NF) based on real-time functional magnetic resonance imaging (rt-fMRI) is an exciting neuroimaging application. In most rt-fMRI NF studies, the activity level of a single region of interest (ROI) is provided as a feedback signal and the part ...

Ieee-Inst Electrical Electronics Engineers Inc2017

In Silico Brain Imaging Physically-plausible Methods for Visualizing Neocortical Microcircuitry

Marwan Muhammad Ahmed Abdellah

The recent years have witnessed growing interest in the power of scientific visualization for simulation-based neuroscience. The research presented in this thesis develops methods to generate physically-realistic visualizations of neocortical models recons ...

EPFL2017

Neuromapp: A Mini-application Framework to Improve Neural Simulators

Felix Schürmann, Judit Planas Carbonell, Francesco Cremonesi, Timothée Ewart, Fabien Jonathan Delalondre

The increasing complexity and heterogeneity of extreme scale systems makes the optimization of large scale scientific applications particularly challenging. Efficiently leveraging these complex systems requires a great deal of technical expertise and a con ...

Springer International Publishing2017